Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections

Michalia, M.; Kompoti, M.; Koutsikou, A.; Paridou, A.; Giannopoulou, P.; Trikka-Graphakos, E.; Clouva-Molyvdas, P.
March 2009
Intensive Care Medicine;Mar2009, Vol. 35 Issue 3, p448
Academic Journal
To investigate the role of diabetes as risk factor for ICU-acquired bloodstream infections (BSI). Prospective observational study. A general eight-bed ICU of a tertiary hospital. Three hundred and forty-three consecutive patients (63 diabetic and 280 nondiabetic) admitted in the ICU. BSI episodes in the ICU were recorded and classified as primary, secondary, catheter-related and mixed according to strict criteria. In all patients, blood glucose was strictly controlled with a continuous insulin infusion within a range of 80–120 mg/dl. One-hundred and eighteen patients (34.4%) developed at least one BSI episode. Diabetic patients had an increased probability of developing at least one BSI episode compared with nondiabetic patients (hazard ratio = 1.66, 95% confidence interval 1.04–2.64, P = 0.034) in a Cox proportional hazards regression model adjusting for age, gender, admission category and APACHE II score at admission in the ICU and comorbidities. Despite strict glycemic control, diabetic patients have a 1.7-fold probability of developing an ICU-acquired BSI compared to nondiabetic subjects.


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