A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease

Irman, Brant A.; Sauver, Jennifer L. St.; Jacobson, Debra J.; McGree, Michaela E.; Nehra, Ajay; Lieber, Michael M.; Roger, Véronique L.; Jacobsen, Steven J.
February 2009
Mayo Clinic Proceedings;Feb2009, Vol. 84 Issue 2, p108
Academic Journal
To assess the association between erectile dysfunction (ED) and the long-term risk of coronary artery disease (CAD) and the role of age as a modifier of this association. PARTICIPANTS AND METHODS: From January 1, 1996, to December 31, 2005, we biennially screened a random sample of 1402 community-dwelling men with regular sexual partners and without known CAD for the presence of ED. Incidence densities of CAD were calculated after age stratification and adjusted for potential confounders by time-dependent Cox proportional hazards models. RESULTS: The prevalence of ED was 2% for men aged 40 to 49 years, 6% for men aged 50 to 59 years, 17% for men aged 60 to 69 years, and 39% for men aged 70 years or older. The CAD incidence densities per 1000 person-years for men without ED in each age group were 0.94(40-49 years), 5.09 (50-59 years), 10.72 (60-69 years), and 23.30 (≥70 years). For men with ED, the incidence densities of CAD for each age group were 48.52 (40-49 years), 27.15(50-59 years), 23.97(60-69 years), and 29.63 (≥70 years). CONCLUSION: ED and CAD may be differing manifestations of a common underlying vascular pathology. When ED occurs in a younger man, it Is associated with a marked increase in the risk of future cardiac events, whereas in older men, ED appears to be of little prognostic importance. Young men with ED may be ideal candidates for cardiovascular risk factor screening and medical Intervention.


Related Articles

  • LOX-1, a new marker of risk and prognosis in coronary artery disease? Lubrano, Valter; Balzan, Silvana // Molecular & Cellular Biochemistry;Nov2013, Vol. 383 Issue 1/2, p223 

    The development of atherosclerosis is caused by the accumulation of lipid, inflammatory cytokine production, and the large amount of inflammatory cells in the arterial wall. It is now established that the presence of oxidized low-density lipoproteins (ox-LDL) has an important role in the...

  • Hyperinsulinemia: A risk factor for ischemic heart disease in men.  // Modern Medicine;Jul96, Vol. 64 Issue 7, p51 

    Presents an abstract on the article `Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease,' by B. Lamarche, P. Mauriege et al published in the April 11, 1996 issue of the `New England Journal of Medicine'.

  • Still risky after sixty.  // Consumer Reports on Health;Nov96, Vol. 8 Issue 11, p129 

    Studies the link between high blood pressure, high cholesterol levels and other factors with the increased risk of coronary heart disease in middle-aged people. Results of researches conducted on the subject; Risk factors increasing heart-attack rate; Factors affecting expected life spans.

  • Attenuated heart rate during exercise is a warning.  // Patient Care;6/15/1996, Vol. 30 Issue 11, p249 

    Presents an abstract of the report `Impaired heart rate response to graded exercise: Prognostic implications of chronotropic incompetence in the Framingham Heart Study,' by M.S. Lauer, P.M. Okin, et al, published in the 1996 edition of the `Circulation.'

  • New CAD risk factors: Interesting, but how useful? Pinkowish, Mary Desmond; Carney, Robert M.; Cohen, Jerome D.; Rosenson, Robert // Patient Care;6/15/1998, Vol. 32 Issue 11, p134 

    Focuses on the risk factors associated with coronary artery disease (CAD). Detailed information on the risk factors associated with CAD; Information on whether physicians should screen patients for more than the traditional risk factors; Usefulness of these risk factors in the treatment of CAD....

  • Risk factors: What are your personal odds?  // Esquire;Oct95, Vol. 124 Issue 4, p150 

    Lists risk factors associated with coronary-artery disease (CAD). Includes elevated cholesterol levels; High-blood pressure; Obesity; Diabetes.

  • Do doctors accurately assess coronary risk in their patients? Preliminary results of the... Grover, Steven A.; Lowensteyn, Iilka // BMJ: British Medical Journal (International Edition);4/15/95, Vol. 310 Issue 6985, p975 

    Evaluates the ability of doctors in primary care to assess risk patients' risk of coronary heart disease. Use of questionnaire survey; Difficulty of assessing coronary risk despite presence of guidelines on targeting patients; Need to develop additional strategies to help doctors assess their...

  • Low job control and risk of coronary heart disease in Whitehall II (prospective cohort) study. Bosma, Hans; Marmot, Michael G. // BMJ: British Medical Journal (International Edition);02/22/97, Vol. 314 Issue 7080, p558 

    Assesses the association between adverse psychosocial characteristics at work and risk of coronary heart disease among male and female civil servants. Assessment of risk of newly reported coronary heart disease in men and women with low job control; Link between low control in the work...

  • Many adults whose mothers had early CHD say they didn't know they are also at risk.  // Modern Medicine;Jun98, Vol. 66 Issue 6, p36 

    Presents an abstract of the article `Risk Factors in the Offspring of Women With Premature Coronary Heart Disease,' by J.K. Allen and R.S. Blumenthal from the `American Heart Journal,' dated March 1998.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics