Von der Identifizierung neurofunktioneller Systeme zur Individualisierung der Therapie schizophrener Störungen

O. Gruber; P. Falkai
January 2009
Der Nervenarzt;Jan2009, Vol. 80 Issue 1, p12
Academic Journal
Zusammenfassung  Dieser Beitrag skizziert die Rolle der systemischen Neurowissenschaften in der Erforschung der neurobiologischen Grundlagen schizophrener und anderer psychotischer Störungen. Zudem wird die Entwicklung diagnostischer und prognostischer Instrumente, welche zur Individualisierung und Optimierung der medikamentösen Behandlung dieser Störungen beitragen können, dargestellt. Es werden präklinische und klinische Studien zur Physiologie und Pathophysiologie des menschlichen Arbeitsgedächtnisses referiert, auf deren Basis neurofunktionelle intermediäre Phänotypen etabliert werden können, die angesichts des bisher weitgehenden Fehlens identifizierter pathologischer Substrate als biologische Marker zur Diagnose tatsächlicher Krankheitsentitäten dienen könnten. Durch die Anwendung funktionell-hirnbildgebender Verfahren könnten damit Subtypen von bisher einheitlich klassifizierten psychiatrischen Störungsbildern erstmals objektiv festgestellt werden, und diese Präzisierung der Diagnose dürfte auch eine Spezifizierung und Optimierung der Therapie ermöglichen.


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