Immunosuppression for liver transplantation

E K Geissler
March 2009
Gut;Mar2009, Vol. 58 Issue 3, p452
Academic Journal
In the last few decades liver transplantation (LTx) has become a reliable life-saving procedure for patients with chronic end-stage liver diseases. LTx has an outstanding success rate in the first few years after allografting, especially considering that many patients are on the brink of survival at the time of transplantation. The success of LTx is owed to the pioneers who developed the surgical procedures and to researchers who discovered the medications to help prevent immunological rejection of allografts. However, several problems continue to impose serious limits on LTx today, including a shortage of donor livers, recurrence of disease (eg, hepatitis, hepatocellular cancer), preservation of long-term allograft function and the side effects of anti-rejection drugs. While the dilemma of organ shortage is not a focus of this review, we will address the latter issues as they relate to the "oldest" and "newest" approaches to immunosuppression, and discuss the prospect that recipients could potentially be made immunologically tolerant to liver transplants. Due to the critical shortage of organs, new strategies to preserve transplanted liver allografts for the longest possible time are of paramount importance.


Related Articles

  • THE USE OF HYPOTHERMIA, HYPERBARIA, AND METABOLIC INHIBITION IN ORGAN PRESERVATION. Feemster, John A.; Idezuki, Yasuo; Dietzman, Ronald H.; Lillehei, Richard C.; Manax, William G. // Vascular Surgery;Jun1970, Vol. 4 Issue 2, p141 

    Discusses the use of hypothermia, hyperbaria, and metabolic inhibition in organ preservation. Importance of maintaining cellular stability in organ transplantation; Definition of hypothermia; Ways to reduce oxidative metabolism.

  • Giant Aneurysm of the Splenic Artery. Bornet, Pierre; Medjoubi, Sid-Ali; Tissot, Alain; Jurado, Andres; Hibonr, Jacques; Terris, Claude // Angiology;Apr2000, Vol. 51 Issue 4, p343 

    Giant aneurysms of the splenic artery larger than 10 cm are rare. The size of splenic aneurysms rarely exceeds 3 cm. Aneurysms that are often symptomatic because of their size must be treated rapidly before rupture. An etiologic and diagnostic evaluation with computed tomography and selective...

  • Donor heart preservation: history and current status in terms of translational medicine. Minasian, S. M.; Galagudza, M. M.; Dmitriev, Yu. V.; Karpov, A. A.; Bobrova, E. A.; Krasichkov, A. S.; Grigoriev, E. B.; Vlasov, T. D. // Regional Haemodynamics & Microcirculation;2014, Vol. 13 Issue 3, p4 

    The preservation of donor heart is the important problem of the transplantation and cardiac surgery. Despite the progress made, the need for further research on this issue is substantial. This review highlights the latest progress in terms of donor heart preservation and provides a focus for the...

  • Resuscitating heart transplantation: the donation after circulatory determined death donor. Messer, Simon; Large, Stephen // European Journal of Cardio-Thoracic Surgery;Jan2016, Vol. 49 Issue 1, p1 

    The authors present insights on myocardial preservation for heart transplantation in Great Britain. Topics discussed include the demand for heart transplantation in Great Britain, the history of donation after circulatory determined death heart transplantation, and abdominal donation after...

  • An alternative surgical technique for caval preservation in liver transplantation. Doria, Cataldo; Bodzin, Adam S.; Frank, Adam M.; Maley, Warren R.; Ramirez, Carlo B. // Journal of Gastrointestinal Surgery;Jun2010, Vol. 14 Issue 6, p1040 

    Introduction: The results of orthotopic liver transplantation in patients with end-stage liver disease continue to improve. Refinements in surgical techniques represent an important part of this improvement.Materials and Methods: With the advent of split-liver and...

  • Liver trauma. Gilbert, Rob; Ashwood, Neil // Trauma;Jul2007, Vol. 9 Issue 3, p171 

    For years partial meniscectomy has been the mainstay of treatment for torn knee menisci. Innovations in surgical techniques have led to the preservation of meniscal tissue. These developments have come in the form of meniscal repair and replacement/transplant. This review aims to assess the...

  • Nasty Infections. Kalb, Claudia; Carmichael, Mary // Newsweek;8/26/2002, Vol. 140 Issue 9, p48 

    Reports on health problems related to the transplantation of implants harvested from cadavers. Problems associated with these products, including tissue contamination; Laws regulating tissue banks; Accreditation of tissue banks.

  • PLASTICS MAY SOON REPLACE SPARE PARTS TAKEN FROM DEAD.  // Ebony;Apr1953, Vol. 8 Issue 6, p18 

    The article reveals how African Americans have played a prominent role in medical science for the preservation and replacement of parts of the human body. For example, the knee plate developed by well renowned Harlem surgeon Louis Wright was used by surgeons at the New York Hospital for Special...

  • Surgeons Successfully Complete the First Human Limb Transplant. Loveday, Veronica // Encyclopedia of Science in the Twentieth Century;2006 Biology, Vol. 1, p7 

    The successful completion of the first human limb transplant is discussed. Before the world's first successful hand transplant in 1998, the only known attempted human limb transplant took place in Ecuador in 1964. Surgeons tried to attach the hand of a donor to another patient's arm, but the...


Read the Article


Sign out of this library

Other Topics