Travel Practices of Solid Organ Transplant Recipients

Mileno, Maria D.
February 2009
Travel Medicine Advisor;Feb2009, Vol. 19 Issue 2, p10
The risks for illness acquired during travel are greater in immunocompromised travelers. Solid organ transplantation poses increased potential for acquisition of new fungal infections, given impaired cell-mediated immunity caused by immunosuppressive drug regimens. Impaired immunity also may lead to increased morbidity from bacterial infections common to travelers such as Salmonella sp, Listeria monocytogenes, Mycobacteria, and Legionella sp. The currently reviewed survey of travel patterns has assessed more than 1100 patients who had undergone solid organ transplantation at Mayo Clinic using a self-administered anonymous questionnaire. Most traveled to low-risk regions and had low rates of travel-associated illness. However, 18% of the group who traveled to high-infection risk destinations such as Asia, Central or South America, Africa, or the Middle East developed illness requiring medical attention during travel. One traveler developed allograft rejection. Men, in general, and persons who were born outside of the United States and Canada were more likely to travel to high-infection risk destinations. Those traveling for the purpose of visiting friends and relatives are reported to be more likely to contract infections due to longer stays and higher risk-taking behavior. Of note, preventive measures were inconsistent, with fewer than 50% of these immunocompromised travelers to high-risk destinations reporting use of DEET. Of 1134 respondents, 303 reported travel outside of the United States and Canada after transplantation. Ninety-six percent of these travelers reported that they did not seek pre-travel advice prior to travel. Travel-related illness requiring medical attention occurred at a rate comparable to that of non-immunocompromised persons (8%), except for 49 persons who traveled to high-infection risk destinations. Of this group, 18% experienced severe illness.


Related Articles

  • Xenotransplantation: Past Achievements and Future Promise. Dwyer, Karen M; Cowan, Peter J; d�Apice, Anthony J. F // Heart, Lung & Circulation;Apr2002, Vol. 11 Issue 1, p32 

    Xenotransplantation offers a potential solution to the shortfall in donor organs for human transplantation. This review describes the barriers to xenotransplantation and the progress that has been made towards making it a clinical reality. Data from preclinical pig-to-primate cardiac and...

  • Organ Cowboy. Sinha, Gunjan // Popular Science;Oct99, Vol. 255 Issue 4, p68 

    Provides information on animal-to-human transplants. Why a pig organ is literally suffocated within minutes of being transplanted, as the recipient's immune cells surround the organ and choke its blood supply; Part of the rejection problem solved by genetic engineering; Critical factor in...

  • Co-Stimulatory Blockade and Tolerance Induction in Transplantation. Bartlett, A.; McCall, J.; Munn, S. // BioDrugs;2001, Vol. 15 Issue 8, p491 

    Recipients of organ and tissue transplants require lifelong immunosuppression to prevent rejection. Better understanding of the processes culminating in allograft rejection has led to novel approaches to modulating the immune response. Co-stimulatory signals between antigen-presenting and...

  • France -- allergic reactions to transplants.  // Nutrition Health Review: The Consumer's Medical Journal;1999, Issue 79, p5 

    Reports on a case of organ transplantation in France where allergy was passed from donor to recipient. Donor of liver and kidney with peanut allergy; Reactions from male recipient of the liver and female recipient of the kidney.

  • Delayed Graft Function or Early Rejection May Not Lead to Failure.  // Kidney;Mar/Apr98, Vol. 7 Issue 2, p75 

    Discusses the abstract of the article 'Long-term graft outcome is not necessarily affected by delayed onset of graft function and early acute rejection,' by S.R.K. Lea, H.M. Isoniemi et al, published in the 1997 issue of the ' Transplantation' journal.

  • Randomized comparison of triple therapy and antithymocyte globulin induction treatment after simultaneous pancreas-kidney transplantation. Cantarovich, Diego; Karam, Georges; Giral-Classe, Magali; Hourmant, Maryvonne; Dantal, Jacques; Blancho, Gilles; Le Normand, Loïc; Soulillou, Jean-Paul // Kidney International;Oct1998, Vol. 54 Issue 4, p1351 

    Randomized comparison of triple therapy and antithymocyte globulin induction treatment after simultaneous pancreas-kidney transplantation. Background . The incidence of acute rejection is considered to be higher after simultaneous pancreas-kidney (SPK) transplantation as compared to renal...

  • This little piggy had none. Cohen, Philip // New Scientist;1/12/2002, Vol. 173 Issue 2325, p7 

    Examines the prevention of pig organs being rejected by human body in the United States. Evaluation of the gene for alpha-1,3-galactosyltransferase to prevent hyperacute rejection; Requirement for tolerance therapy for xenotransplantation; Forms in preventing immune rejection.

  • Association of Viral Genome with Graft Loss in Children after Cardiac Transplantation. Shirali, Girish S.; Ni, Jiyuan; Chinnock, Richard E.; Johnston, Joyce K.; Rosenthal, Geoffrey L.; Bowles, Neil E.; Towbin, Jeffrey A. // New England Journal of Medicine;05/17/2001, Vol. 344 Issue 20, p1498 

    Background: The survival of recipients of cardiac allografts is limited by rejection and coronary vasculopathy. The purpose of this study in children who had received heart transplants was to evaluate the cardiac allografts for myocardial viral infections and to determine whether the presence of...

  • Therapy for Acute Rejection in Pediatric Organ Transplant Recipients. Debray, D.; Furlan, V.; Baudouin, V.; Houyel, L.; Lacaille, F.; Chardot, C. // Pediatric Drugs;2003, Vol. 5 Issue 2, p81 

    Despite the availability of potent immunosuppressive drugs, rejection after organ transplantation in children remains a serious concern, and may lead to significant morbidity, graft loss, and death of the patient. Acute graft rejection in pediatric recipients is first treated with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics