Od Wenus z Willendorfu do leptyny -- historia odkrycia tej cytokiny i jej powiązanie z męskim układem rozrodczym człowieka

Malendowicz, Witold; Kwias, Zbigniew
September 2008
Polish Journal of Urology / Urologia Polska;2008, Vol. 61 Issue 4, p272
Academic Journal
From the beginning of the human species, obesity was accompanied by us. Obesity fascinated all people generations, obese persons were illustrated in the art, and frequently reported as a medical cases. At the end of XX century progress in biomedicine allowed to recognize numerous factors involved in control of energy homeostasis. Earlier two recessive mutations ob/ob and db/db associated with massive obesity, were discovered in years 1950-1960. Subsequent experiments with parabiotic mice demonstrated the presence of blood - borne factor(s) involved in control of obesity. In 1994 that factor was identified and named leptin (from Greek leptos). Secreted primarily by the white adipose tissue, this peptide hormone appeared to be a molecule linking body fat mass with the hypothalamus. The primary function of leptin is to decrease caloric intake and increase energy expenditure. Moreover, leptin is involved in regulating numerous biological systems and organs. This review presents the most important facts on leptin action within the human male reproductive system.


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