Mouse study prompts experts to revisit the promise of leptin

Siva, Nayanah
February 2009
Nature Medicine;Feb2009, Vol. 15 Issue 2, p122
Academic Journal
This article presents information about promising research on the appetite-suppressing hormone leptin. Leptin was anticipated to become the miracle drug for obesity, but the large majority of obese people were resistant to leptin. Umut Ozcan of Harvard Medical School has discovered that leptin resistance is caused by system stress that causes signals to prevent leptin from acting. Ozcan's research with chaperone molecules that prevent the obstructing signals is promising.


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