Torturing a blood vessel

Patterson, Cam
February 2009
Nature Medicine;Feb2009, Vol. 15 Issue 2, p137
Academic Journal
The article focuses on research into cerebral cavernous malformations (CCM) and efforts to develop animal models to study the condition. It states that three mutated genes have been identified in CCMs. It mentions that the proteins that these genes are responsible to mediate cellular responses to stress that requires Rho-family GTPase activation and mitogen-activated protein kinase signaling. It comments on the difficulty in developing animal models that mimic the lesions found in CCM patients.


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