TITLE

The effect of daily administration of IL-18 on cardiac structure and function

AUTHOR(S)
Platis, A.; Yu, Q.; Moore, D.; Khojeini, E. V.; Tsau, P.; Larson, D. F.
PUB. DATE
July 2008
SOURCE
Perfusion;Jul2008, Vol. 23 Issue 4, p237
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Recently, the cytokine Interleukin-18 (IL-18) has been shown to be increased as a result of cardiac surgery. Elevated IL-18 has been associated with neurological dysfunction, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) post open-heart surgery. The intent of the study contained herein was to determine the effect of IL-18 administration on cardiac function and structure. Eight C57BL/6 female mice were treated daily with 0.5μg/mouse of recombinant IL-18 for 7 days. Long axis echocardiography (ECHO) measurements of the anatomical and hemodynamic function of the heart for all mice were studied 24h after the last dose. The left ventricular wet weights increased from 84 ± 1 to 93 ± 3 mg when comparing the placebo (n = 8) with the IL-18 groups, respectively (p = 0.01). With ECHO analysis, IL-18 significantly increased left ventricular (LV) mass, the left atrium dimensions (LA), and the left ventricular posterior wall thickness (LVPW) over the 8-day time period (p < 0.01). There was a 5-fold increase in interstitial cardiac collagen content and a 30% increase in myocyte size in the IL-18 compared with the control groups (p < 0.01). Administration of IL-18 appears to induce interstitial fibrosis and myocyte hypertrophy, resulting in increased ventricular stiffness. Thus, increased IL-18 during and post open-heart surgical procedures may induce left ventricular diastolic dysfunction and affect post-operative outcomes.
ACCESSION #
36361574

 

Related Articles

  • Clot spotting. Hobson, Katherine // U.S. News & World Report;8/12/2002, Vol. 133 Issue 6, p45 

    Mentions that heart surgery and mechanical heart valves often produce tiny blood clots that can travel to the brain. Report in the periodical 'Stroke' which discusses a device that uses ultrasound waves to not only detect clots but determine if they are solid or made from gas bubbles.

  • Effects of protective and conventional mechanical ventilation on pulmonary function and systemic cytokine release after cardiopulmonary bypass. Koner, Ozge; Celebi, Serdar; Balci, Huriye; Cetin, Gurkan; Karaoglu, Kamil; Cakar, Nahit // Intensive Care Medicine;Apr2004, Vol. 30 Issue 4, p620 

    Objective: To evaluate the effects of protective and conventional ventilation with or without positive end-expiratory pressure (PEEP), on systemic tumor necrosis factor-alpha, interleukin-6 levels and pulmonary function during open heart surgery.Design: Prospective,...

  • Editorial. Punjabi, P. P. // Perfusion;Jul2008, Vol. 23 Issue 4, p203 

    The article discusses various reports published within the issue including one by O. Alfieri and colleagues on the versatility of the ReVERSE system for cardioplegia, one by L. K. von Segesser and colleagues on Admiral oxygenator, and one by C. J. Jakobsen and colleagues on intra-aortic balloon...

  • Closure of a Paravalvular Aortic Leak with the Use of 2 AMPLATZER Devices and Real-Time 2- and 3-Dimensional Transesophageal Echocardiography. Hoffmayer, Kurt S.; Zellner, Christian; Kwan, Damon M.; Konety, Suma; Foster, Elyse; Moore, Phillip; Yeghiazarians, Yerem // Texas Heart Institute Journal;2011, Vol. 38 Issue 1, p81 

    Paravalvular leaks are well-recognized sequelae of mechanical aortic valve implantation. Clinical manifestations include hemolysis, arrhythmias, and congestive heart failure. Frequently, patients who receive mechanical aortic valves are poor candidates for repeat valve surgery, and the...

  • Does contrast echocardiography induce increases in markers of myocardial necrosis, inflammation and oxidative stress suggesting myocardial injury? Knebel, Fabian; Schimke, Ingolf; Eddicks, Stephan; Walde, Torsten; Ziebig, Reinhard; Schattke, Sebastian; Baumann, Gert; Borges, Adrian Constantin // Cardiovascular Ultrasound;2005, Vol. 3, p1 

    Background: Contrast echocardiography is a precise tool for the non-invasive assessment of myocardial function and perfusion. Side effects of contrast echocardiography resulting from contrast-agent induced myocardial micro-lesions have been found in animals. The goal of this study is to measure...

  • Tricuspid valve papillary fibroelastoma: an unusual cause of intermittent dyspnea Georghiou, Georgios P.; Erez, Eldad; Vidne, Bernardo A.; Aravot, Dan // European Journal of Cardio-Thoracic Surgery;Mar2003, Vol. 23 Issue 3, p429 

    A 67-year-old woman was referred for investigation of intermittent dyspnea, which was known for years but had been worsening over the previous 3 months. Two-dimensional echocardiography revealed the presence of a mass attached to the anterior leaflet of the tricuspid valve. The patient was...

  • Cardiac surgery in the age of the dinosaurs. Replogle, Robert L. // Perfusion;May2003, Vol. 18 Issue 3, p171 

    This symposium, celebrating the 50th anniversary of the first successful use of the heart-lung machine, sponsored by the American Academy of Cardiovascular Perfusion, provides an opportunity to reflect on the circumstances of the time and the character of the people who made the important...

  • Antegrade cerebral perfusion with hypothermic circulatory arrest: a case report. Fitzgerald, David; Resley, Justin; Speir, Alan; Munoz, Ruben; Hill, Aaron // Perfusion;Sep2003, Vol. 18 Issue 5, p303 

    Techniques for the surgical correction of aortic aneurysms have steadily improved since the first described successful repair in 1955 by DeBakey et al. Despite these improvements, postoperative neurological complications remain a major factor in determining an adverse outcome. By using Deep...

  • Interleukin-6 may predict survival in extracorporeal membrane oxygenation treatment. Risnes, I.; Wagner, K.; Ueland, T.; Mollnes, T. E.; Aukrust, P.; Svennevig, J. L. // Perfusion;May2008, Vol. 23 Issue 3, p173 

    The cytokine network and its association with complement activation during cardiac surgery with cardiopulmonary bypass (CPB) is complex. Extracorporeal membrane oxygenation (ECMO) differs from CPB in duration of days to weeks rather than hours. However, few studies have analyzed the levels of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics