TITLE

CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis

AUTHOR(S)
S E Monstad
PUB. DATE
February 2009
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Feb2009, Vol. 80 Issue 2, p241
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Collapsin response mediator protein 5 (CRMP5) antibodies are often associated with thymoma or small cell lung cancer and paraneoplastic syndromes such as limbic encephalitis (LE). A patient is described with myasthenia gravis who, following thymectomy and immunosuppression, acquired a viral infection and developed LE and increased levels of serum CRMP5 antibodies. The cognitive symptoms improved and CRMP5 antibody levels decreased after plasma exchange, suggesting that CRMP5 antibodies may have contributed to the development of LE.
ACCESSION #
36359228

 

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