TITLE

Downregulation of Inflammatory Responses by Novel Caffeic Acid Ester Derivative by Inhibiting NF-kappa B

AUTHOR(S)
Julie Bose; Vijay Gangan; Swatantra Jain; Sunil Manna
PUB. DATE
January 2009
SOURCE
Journal of Clinical Immunology;Jan2009, Vol. 29 Issue 1, p90
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Introduction  Considering anti-tumorigenic activity of caffeic acid phenyl ester, synthesis of several esterified form of caffeic acid is a novel approach in designing for potent drugs. Results  Our study demonstrates that esterified caffeic acid with methyl vanillate, termed as caffeic acid methyl vanillate ester (CAMVE), blocked inflammatory stimuli-induced inflammatory responses. It decreased amounts of iNOS, Cox-2, and ICAM1 by inhibiting NF-κB through inhibition of IKK activity, IκBα degradation, and p65 nuclear translocation. Conclusion  Overall, our data suggest that novel caffeic acid ester down-regulates inflammatory responses through inhibition of NF-κB and dependent several gene expressions, further suggesting its efficacy as a promising therapeutic agent.
ACCESSION #
36359112

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics