Common Variable Immunodeficiency in Horses is Characterized by B Cell Depletion in Primary and Secondary Lymphoid Tissues

M. Flaminio; Rebecca Tallmadge; Cristina Salles-Gomes; Mary Matychak
January 2009
Journal of Clinical Immunology;Jan2009, Vol. 29 Issue 1, p107
Academic Journal
Abstract Introduction  Common variable immunodeficiency (CVID) in horse patients is characterized by late-onset B cell lymphopenia or depletion, hypo- or agammaglobulinemia, impaired humoral response to tetanus toxoid vaccination, and recurrent fevers and bacterial infections. Discussion  This study describes the clinical and immunologic findings of 14 affected horses (average age 10.7 ± 4.4 years) of both genders (six females, eight males) and different breeds (eight Thoroughbreds, four Quarter Horses, one Warmblood, one Pony). Serial immunological testing in peripheral blood revealed persistent, severe B cell lymphopenia (mean 1.3 ± 2.3% positive cells) in all patients. Serum IgG (range


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