TITLE

Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus in Young Men: Results of a Randomized Controlled Trial Conducted in Orange Farm, South Africa

AUTHOR(S)
Auvert, Bertran; Sobngwi-Tambekou, Joelle; Cutler, Ewalde; Nieuwoudt, Marthi; Lissouba, Pascale; Puren, Adrian; Taljaard, Dirk
PUB. DATE
January 2009
SOURCE
Journal of Infectious Diseases;1/1/2009, Vol. 199 Issue 1, p14
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. A causal association links high-risk human papillomavirus (HR-HPV) and cervical cancer, which is a major public health problem. The objective of the present study was to investigate the association between male circumcision (MC) and the prevalence of HR-HPV among young men. Methods. We used data from aMC trial conducted in Orange Farm, South Africa, among men aged 18-24 years. Urethral swab samples were collected during a period of 262 consecutive days from participants in the intervention (circumcised) and control (uncircumcised) groups who were reporting for a scheduled follow-up visit. Swab samples were analyzed using polymerase chain reaction. HR-HPV prevalence rate ratios (PRRs) were assessed using univariate and multivariate log Poisson regression. Results. In an intention-to-treat analysis, the prevalences of HR-HPV among the intervention and control groups were 14.8% (94/637) and 22.3% (140/627), respectively, with a PRR of 0.66 (0.51- 0.86) (P = .002). Controlling for propensity score and confounders (ethnic group, age, education, sexual behavior [including condom use], marital status, and human immunodeficiency virus status) had no effect on the results. Conclusions. This is the first randomized controlled trial to show a reduction in the prevalence of urethral HR-HPV infection after MC. This finding explains why women with circumcised partners are at a lower risk of cervical cancer than other women.
ACCESSION #
36347908

 

Related Articles

  • Associations between Male Anogenital Human Papillomavirus Infection and Circumcision by Anatomic Site Sampled and Lifetime Number of Female Sex Partners. Nielson, Carrie M.; Schiaffino, Melody K.; Dunne, Eileen F.; Salemi, Jason L.; Giuliano, Anna R. // Journal of Infectious Diseases;1/1/2009, Vol. 199 Issue 1, p7 

    Background. Male circumcision may lower men's risk of human papillomavirus (HPV) infection and reduce transmission to sex partners. Reported associations between circumcision and HPV infection in men have been inconsistent. Methods. Four hundred sixty-three men in 2 US cities were tested at 6...

  • FOR HIM.  // Dolly;Feb2011, Issue 482, p111 

    The article presents questions and answers related to men's health including ways of getting over an infatuation for his girlfriend's best friend and ways of preventing bad breath.

  • Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention. Sobngwi Tambekou, J.; Taljaard, D.; Nieuwoudt, M.; Lissouba, P.; Puren, A.; Auvert, B. // Sexually Transmitted Infections;Apr2009, Vol. 85 Issue 2, p116 

    Objective: To assess the association between male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis using data from a male circumcision randomised controlled trial. Methods: We used data collected during the male circumcision trial conducted in Orange Farm...

  • We Look Marvelous. Balz, Chrissy // Newsweek;9/25/2006, Vol. 148 Issue 13, p11 

    The article reports on the growing trend of couples getting cosmetic procedures together. 37% of plastic surgeons reported doing more procedures on couples in 2006 than they did in 2005. The trend represents a change in attitude about cosmetic procedures by men, who at one time represented a...

  • Younger men, older women. Czape, Chandra; Brody, Liz // Glamour;May99, Vol. 97 Issue 5, p64 

    Shares women's reactions on whether it is alright for women to date younger men who are still minors. Reason given by nearly half of respondents for saying that dating with a minor will not be satisfying; Factors for women to consider before getting into a relationship with a minor.

  • Effect of HSV-2 Serostatus on Acquisition of HIV by Young Men: Results of a Longitudinal Study in Orange Farm, South Africa. Sobngwi-Tambekou, Joelle; Taljaard, Dirk; Lissouba, Pascale; Zarca, Kevin; Puren, Adrian; Lagarde, Emmanuel; Auvert, Bertran // Journal of Infectious Diseases;4/1/2009, Vol. 199 Issue 7, p958 

    Background. The objectives of this study were to assess the impact among young men of herpes simplex virus type 2 (HSV-2) status on the acquisition of human immunodeficiency virus (HIV) and on the protective effect of male circumcision against HIV acquisition. Methods. We used data collected...

  • Get your mate moving. Reeks, Anne // Health (Time Inc. Health);Oct96, Vol. 10 Issue 6, p32 

    Presents advice to women on how to get their men to exercise. Reassurance to one's partner that physical fitness is not a quid pro quo for love; Initiation of exercise habit by making it easy and fun; Exercising at his pace; Devotion of more of workout time to the plan.

  • Men solve your man problems. Mezzafonte, Allison // Glamour;Aug2003, Vol. 101 Issue 8, p113 

    Offers advice on man-woman relationship. Public display of affection; Guy with a personal-hygiene problem; Sexual excitement.

  • Jimmy the Bartender. LARRY; CARL; BERNARD; SEAN; LOUIS; ANDREW // Men's Health;Sep2015, Vol. 30 Issue 7, p37 

    The article presents questions and answers related to men's health, work and relationship with women that include a female colleague who is flirting with a man who have a girlfriend, a home-made cocktail that can impress a woman, and the incapacity of a company to give pay raises.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics