High-resolution photoacoustic imaging with focused laser and ultrasonic beams

Kong, Fanting; Chen, Y. C.; Lloyd, Harriet O.; Silverman, Ronald H.; Kim, Hyung Ham; Cannata, Jonathan M.; Shung, K. Kirk
January 2009
Applied Physics Letters;1/19/2009, Vol. 94 Issue 3, pN.PAG
Academic Journal
We report a photoacoustic imager that utilizes a focused laser beam in combination with a 20 MHz ultrasound focusing transducer to obtain micron-resolution tissue images over a long working distance. The imager is based on a ring transducer that combines ultrasonic and laser beams collinearly and confocally in a monolithic element. The combination of focused laser beam and short pulse irradiation led to significant improvement in lateral and axial resolutions compared to the pulse-echo ultrasonic imaging technique or photoacoustic imaging with an unfocused laser. Potential applications include clinical examination of the eye and characterization of thin and superficial tissues.


Related Articles

  • Counting particles by means of optoacoustics: Potential limits in real solutions. Autrey, Tom; Egerev, Sergey; Foster, Nancy S.; Fokin, Andrey; Ovchinnikov, Oleg // Review of Scientific Instruments;Jan2003, Vol. 74 Issue 1, p628 

    The irradiation of an inhomogeneous liquid sample with a long train of short laser pulses and subsequent recording of a histogram of the magnitudes of the acoustic responses can serve as a diagnostic tool for various applications. The absorption of an incident light by a suspended particle may...

  • Taking the hype out of hypervelocity. Wai Chan; Taylor, Keith // Laser Focus World;Jun2010, Vol. 46 Issue 6, p52 

    The article focuses on the development of ultrahigh-speed framing cameras into a single plug-and-play systems using beamsplitters and wavelength-selective components. It stresses that the utmost importance of the technology is the ability to freeze the motion and achieve a high-quality and high...

  • Femtosecond demodulation source for high-resolution submillimeter spectroscopy. Goyette, Thomas M.; Wei Guo // Applied Physics Letters;12/18/1995, Vol. 67 Issue 25, p3810 

    Develops a tunable femtosecond source for high-resolution submillimeter spectroscopy. Demodulation of mode-locked femtosecond laser pulse train by subpicosecond photoconductive switch; Production of submillimeter wave radiation by the generation of electron hole pairs; Drift of photocarriers to...

  • High-resolution in-source laser spectroscopy in perpendicular geometry. Heinke, R.; Kron, T.; Raeder, S.; Reich, T.; Schönberg, P.; Trümper, M.; Weichhold, C.; Wendt, K. // Hyperfine Interactions;12/15/2016, Vol. 238 Issue 1, p1 

    Operation of the novel laser ion source unit LIST (Laser Ion Source and Trap), operating at the on-line radioactive ion beam facility ISOLDE at CERN allowed for the production of ultra-pure beams of exotic isotopes far-off stability as well as direct isobar-free laser spectroscopy, giving access...

  • High-speed Intravascular Photoacoustic Imaging of Lipid-laden Atherosclerotic Plaque Enabled by a 2-kHz Barium Nitrite Raman Laser. Pu Wang; Teng Ma; Slipchenko, Mikhail N.; Shanshan Liang; Jie Hui; Shung, K. Kirk; Roy, Sukesh; Sturek, Michael; Qifa Zhou; Zhongping Chen; Ji-Xin Cheng // Scientific Reports;11/7/2014, p1 

    Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per...

  • High-resolution laser lithography system based on two-dimensional acousto-optic deflection. Koechlin, Manuel; Poberaj, Gorazd; Günter, Peter // Review of Scientific Instruments;Aug2009, Vol. 80 Issue 8, p085105 

    We present an advanced high-resolution, compact laser lithography system for fast prototyping of complex integrated optics devices comprising microring resonators and photonic crystal structures. Precise and flexible structuring of photoresist patterns is achieved by combing three linear stages...

  • Sensitive detection of optical discrete absorption and lasing of fused silica by the depopulation of the ground state. Bayrakçeken, F. // Applied Physics B: Lasers & Optics;Nov2011, Vol. 105 Issue 3, p573 

    Ultraviolet light induced high resolution optical absorption spectra and resonance coherent fluorescence of spectroscopically pure fused silica have been studied, due to their potential applications in optoelectronics and laser flash spectroscopy for laboratory use, for optical fibers and for...

  • Longitudinal coherence in thermal ghost imaging. Ferri, F.; Magatti, D.; Sala, V. G.; Gatti, A. // Applied Physics Letters;6/30/2008, Vol. 92 Issue 26, p261109 

    We show theoretically and experimentally that lensless ghost imaging with thermal light is fully interpretable in terms of classical statistical optics. The disappearance of the ghost image when the object and the reference planes are located at different distances from the source is due to the...

  • Amino Acid Formation by Electron Irradiation. Cáceres, D.; Bertin, M.; Lafosse, A.; Domaracka, A.; Pliszka, D.; Azria, R. // AIP Conference Proceedings;2006, Vol. 876 Issue 1, p112 

    The origin of amino acid formation in the early years is still not well known. Muñoz Caro and collaborators showed the generation of amino acid by UV irradiation of a mixture of organic molecules reproducing the interstellar media. Although the photochemistry is one of the mechanism which...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics