TITLE

A Fast Stripping Continuous Cyclic Voltammetry Method for Determination of Ultra Trace Amounts of Nalidixic Acid

AUTHOR(S)
Norouzi, Parviz; Ganjali, Mohammad Reza; Larijani, Bagher; Karamdoust, Sanaz
PUB. DATE
November 2008
SOURCE
Croatica Chemica Acta;Nov2008, Vol. 81 Issue 3, p423
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In recent years, modern electroanalytical techniques, especially cyclic voltammetry, are becoming increasingly important in the determination of pharmaceutical products. This study presents a novel method for the determination of nalidixic acid (NA) in flow-injection systems, called fast stripping continuous cyclic voltammetry. This technique is simple, precise, accurate and time saving compared to similar methods. Initially, the effects of several method parameters on sensitivity were tested. Thus, the potential waveform was applied to an Au disk microelectrode in a continuous way. After a series of experiments, it was concluded that the best performance was achieved with the basic parameters set at pH = 2, sweep rate of 60 V s-1, accumulation potential 100 mV and accumulation time 0.7 s. The detection limit was 0.07 pg mL-1 and the relative standard deviation was 2.2 % at the concentration of 10 nmol dm-3 for 10 runs. Major advantages of this method are (i) it is no longer necessary to remove oxygen from the test solution, (ii) fast determination of similar compounds by several chromatographic methods is possible, and (iii) the achieved detection limit is low.
ACCESSION #
36330423

 

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