TITLE

Why are trials in palliative care so difficult?

AUTHOR(S)
Saunders, Dame Cicely; Twycross, Robert
PUB. DATE
September 2000
SOURCE
Palliative Medicine;Sep2000, Vol. 14 Issue 5, p435
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Comments on G.E. Grande and C.J. Todd's description of some of the problems in carrying out 'pragmatic' trials in palliative care, published in the September 2000 issue of 'Palliative Medicine.' Failure of the authors to mention studies published in the 1970s which had a major impact on the delivery of palliative care worldwide; Importance of randomized controlled trials of drug therapy in this field.
ACCESSION #
3633015

 

Related Articles

  • Need for rigorous assessment of palliative care. McQuay, Henry; Moore, Andrew // BMJ: British Medical Journal (International Edition);11/19/94, Vol. 309 Issue 6965, p1315 

    Focuses on the need for rigorous assessment of palliative care service in Great Britain. Factors influencing the effectiveness of palliative treatment; Failure to evaluate a palliative care service with a randomized controlled trial; Problems of ethics of randomization in palliative care practice.

  • Why are trials in palliative care so difficult? Grande, G.; Todd, C. // Palliative Medicine;Jan2000, Vol. 14 Issue 1, p69 

    Studies the reasons behind the difficulties in the conduct of randomized controlled trials (RCT) in palliative care. Challenges in terms of trial design and ethics; Issues that should be considered by researchers planning to conduct RCT in the field; Role of qualitative research methods in RCT.

  • Lack of concealment may lead to selection bias in cluster randomized trials of palliative care. Jordhøy, MS; Fayers, PM; Ahlner-Elmqvist, M; Kaasa, S // Palliative Medicine;Jan2002, Vol. 16 Issue 1, p43 

    Comprehensive palliative care programs are often implemented on a community level, and to evaluate such interventions, randomization by cluster (community) may be the only feasible method. In trials randomizing individual subjects, the importance of proper concealment has been stressed. In...

  • Cluster-randomized trials. Fayers, PM; Jordhøy, MS; Kaasa, S // Palliative Medicine;Jan2002, Vol. 16 Issue 1, p69 

    Looks at cluster-randomized trials in palliative medicine. Characteristics of cluster-randomized trials; Benefits of cluster-randomized trials; Intracluster correlations; Sample size estimation.

  • Clinical research in palliative care: patient populations, symptoms, interventions and endpoints. Mazzocato, C.; Sweeney, C.; Bruera, E. // Palliative Medicine;Mar2001, Vol. 15 Issue 2, p163 

    Examines the factors which are vital for good clinical research in palliative care. Purpose of palliative care; Significance of the design chosen by investigator on the credibility of the research findings; Comparison between parallel and crossover trials.

  • Clinical research in palliative care: choice of trial design. Mazzocato, C.; Sweeney, C.; Bruera, E. // Palliative Medicine;May2001, Vol. 15 Issue 3, p261 

    Discusses the appropriate choice of trial design in palliative medicine. Types of clinical trials; Methodological obstacles in the design and execution of trials; Advantages and disadvantages of parallel and crossover trials.

  • Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise. Stephens, R J; Hopwood, P; Girling, D J // British Journal of Cancer;2/1/99, Vol. 79 Issue 3/4, p538 

    The assessment of symptom palliation is an essential component of many treatment comparisons in clinical trials, yet an extensive literature search revealed no consensus as to its precise definition, which could embrace relief of symptoms, time to their onset, duration, degree, as well as...

  • Challenges in palliative care research; recruitment, attrition and compliance: experience from a randomized controlled trial. Jordhy, M.; Kaasa, S.; Fayers, P.; vreness, T.; Underland, G.; Ahlner-Elmqvist, M. // Palliative Medicine;1999, Vol. 13 Issue 4, p299 

    Randomized controlled trials (RCTs) in palliative cancer care often experience methodological problems. In this paper we discuss issues of major concern, including recruitment, patient attrition and compliance, arising from an RCT that compared comprehensive palliative care to conventional care....

  • Evaluation of a palliative care service: problems and pitfalls. McWhinney, Ian R.; Bass, Martin J.; Donner, Allan // BMJ: British Medical Journal (International Edition);11/19/94, Vol. 309 Issue 6965, p1340 

    Evaluates the palliative care home service in Great Britain. Details on ethical problems raised by randomization of dying patients; Impracticability of randomized trials method in evaluating palliative care; Problems in evaluating the service. INSET: Research implications.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics