Haulica, I.; Bild, W.; Popescu, R.
April 2007
Acta Endocrinologica (1841-0987);Apr-Jun2007, Vol. 3 Issue 2, p225
Academic Journal
The article offers information on the enzymatic cascade for the circulating and local biosynthesis of angiotensin peptides. There are two categories of tissue renin-like enzymes, the tissue cathepsins G, E and D and the tissue renin-like enzymes represented by tonin. Aside from carboxypeptidases, neural endopeptidase, and prolyl endopeptidase, the aminopeptidases participate as angiotensinases in the biochemical pathway of angiotensin peptide inactivation. It was found that many tissues and organs of an intrinsic angiotensin-generating system is responsive for the locally-formed bioactive angiotensins.


Related Articles

  • ACE and ACE2 Activity in Diabetic Mice. Wysocki, Jan; Ye, Minghao; Soler, Maria José; Gurley, Susan B.; Xiao, Hong D.; Bernstein, Kenneth E.; Coffman, Thomas M.; Chen, Sheldon; Batlle, Daniel // Diabetes;Jul2006, Vol. 55 Issue 7, p2132 

    ACE-related carboxypeptidase (ACE2) may counterbalance the angiotensin (ANG) II-promoting effects of ACE in tissues where both enzymes are found. Alterations in renal ACE and ACE2 expression have been described in experimental models of diabetes, but ACE2 activity was not assessed in previous...

  • Enkephalin Degrading Enzymes: Metalloproteases with High Potential for Drug Development. Khaket, Tejinder Pal; Singh, Jasbir; Attri, Pooja; Dhanda, Suman // Current Pharmaceutical Design;1/11/2012, Vol. 18 Issue 2, p220 

    Enkephalins play a great role in management of pain, blood pressure, hypertension and cardiovascular diseases. Enkephalins are short-lived molecules being rapidly hydrolyzed following their synaptic release by enkephalin degrading enzymes. The inhibitors of enkephalin degrading enzymes are able...

  • The Zinc Metallopeptidase Family: New Faces, New Functions. Lew, Rebecca A. // Protein & Peptide Letters;Oct2004, Vol. 11 Issue 5, p407 

    The abstract for this article is not available.

  • The Intracellular Distribution and Secretion of Endopeptidases 24.15 415 (Ec and 24.16 (Ec Ferro, Emer S.; Carre�o, Fl�via R.; Go�i, Camila; Garrido, Paula A.G.; Guimar�es, Alessander O.; Castro, Leandro M.; Oliveira, Vitor; Araujo, Maur�cio C.; Rioli, Vanessa; Gomes, Marcelo D.; Fontenele-Neto, Jos� Domingues; Hyslop, Stephen // Protein & Peptide Letters;Oct2004, Vol. 11 Issue 5, p415 

    Endopeptidase 24.15 (EC; EP24.15) and endopeptidase 24.16 (EC; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of...

  • Targeting the Renin-angiotensin System: What's New? Leckie, B. J. // Current Medicinal Chemistry - Cardiovascular & Hematological Age;Jan2005, Vol. 3 Issue 1, p23 

    The renin-angiotensin system is a key target for drugs combating cardiovascular disease. Angiotensinconverting enzyme (ACE) inhibitors and angiotensin receptor type-1 (AT1 receptor) blockers are well known. However, angiotensin peptides can be generated through a number of pathways besides the...

  • Crystal structure of the human angiotensin-converting enzyme–lisinopril complex. Natesh, Ramanathan; Schwager, Sylva L. U.; Sturrock, Edward D.; Acharya, K. Ravi // Nature;1/30/2003, Vol. 421 Issue 6922, p551 

    Angiotensin-converting enzyme (ACE) has a critical role in cardiovascular function by cleaving the carboxy terminal His-Leu dipeptide from angiotensin I to produce a potent vasopressor octapeptide, angiotensin II. Inhibitors of ACE are a first line of therapy for hypertension, heart failure,...

  • Structure-based drug design: An ACE surprise. Frantz, Simon // Nature Reviews Drug Discovery;Apr2003, Vol. 2 Issue 4, p252 

    Reports on the determination of the X-ray structure of angiotensin converting enzyme (ACE) and its complex with the widely used ACE inhibitor lisinopril at high resolution. Resemblance of ACE to rat neurolysin and Pyrococcus furiosus carboxypeptidase.

  • Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells. Ng, Hwee-Yeong; Yisireyili, Maimaiti; Saito, Shinichi; Lee, Chien-Te; Adelibieke, Yelixiati; Nishijima, Fuyuhiko; Niwa, Toshimitsu // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    : Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1–7)/Mas receptor axis counteracts the deleterious actions of Ang II. ACE2 exerts its actions by cleaving Ang II into...

  • The Future of Angiotensin II Inhibition in Cardiovascular Medicine. Meier, Pascal; Maillard, Marc; Burnier, Michel // Current Drug Targets - Cardiovascular & Haematological Disorders;Feb2005, Vol. 5 Issue 1, p15 

    Drugs, which interfere with the renin-angiotensin-aldosterone cascade such as angiotensin converting enzyme (ACE) inhibitors, have been available to clinicians for more than 20 years. They are now recognized as a very effective approach to treat patients with hypertension, heart failure,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics