Familial Permanent Neonatal Diabetes with KCNJ11 Mutation and the Response to Glyburide Therapy -- A Three-Year Follow-Up

Begum-Hasan, Jahanara; Polychronakos, Constantine; Brill, Herbert
September 2008
Journal of Pediatric Endocrinology & Metabolism;Sep2008, Vol. 21 Issue 9, p895
Academic Journal
The article discusses the follow-up to the case of glyburide therapy in a child with permanent neonatal diabetes mellitus (PND) born to a 19-year-old mother who is suffering from congenital diabetes mellitus. According to genetic analysis, both child and mother have KCNJ11 mutation. It is noted that glucose excursion decreases were observed in the infant. The follow-up also revealed that the patient had 3 to 10 episodes of hypoglycemia weekly and some seizures. It is asserted that PND is well treated by sulfonylurea therapy.


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