Valve-based flow focusing for drop formation

Abate, Adam R.; Romanowsky, Mark B.; Agresti, Jeremy J.; Weitz, David A.
January 2009
Applied Physics Letters;1/12/2009, Vol. 94 Issue 2, pN.PAG
Academic Journal
Microfluidic devices can produce highly monodisperse drops at kilohertz rates using flow-focus drop formation. We use single-layer membrane valves to control, in real time, the dimensions of the flow-focus drop makers. This allows drop size and frequency to be controlled in real time and without adjusting flow rates.


Related Articles

  • Chaotic mixing in microfluidic devices driven by oscillatory cross flow. Phelan, Frederick R.; Hughes, Nicholas R.; Pathak, Jai A. // Physics of Fluids;Feb2008, Vol. 20 Issue 2, p023101 

    The kinematics of oscillatory cross flow has been studied numerically as a means for generating chaotic mixing in microfluidic devices for both confined and continuous throughput flow configurations. The flow is analyzed using numerical simulation of the unsteady Navier–Stokes equations...

  • Creation, transportation, and coalescence of liquid drops by means of a light beam. Bezuglyi, B.; Ivanova, N. // Fluid Dynamics;Mar2006, Vol. 41 Issue 2, p278 

    A novel principle of manipulation of discrete drops using concentration-capillary forces controlled by the thermal action of a light beam is proposed. The drops are created by the light beam in a thin layer of absorbing solution and in a film of that solution beneath an air bubble in the cell....

  • Impact of Viscosity Ratio on the Dynamics of Droplet Breakup in a Microfluidic Flow Focusing Device. Lee, Wingki; Walker, Lynn M.; Anna, Shelley L. // AIP Conference Proceedings;7/7/2008, Vol. 1027 Issue 1, p994 

    The flow focusing geometry is one of several used in microfluidic devices to form monodisperse emulsion droplets. The addition of surfactant leads to the observation of a thread formation regime which has features similar to tip-streaming seen in deformed droplets. This thread formation regime...

  • Droplet breakup in an asymmetric microfluidic T junction. Bedram, Ahmad; Moosavi, Ali // European Physical Journal E -- Soft Matter;Aug2011, Vol. 34 Issue 8, p1 

    Breakup of non-uniform droplets in an asymmetric T junction consisting of an inlet channel and two different-size outlet channels has been investigated numerically. Also, an analytical approach in the limit of the lubrication approximation has been extended to provide some analytical relations...

  • Numerical evidence of smooth self-similar dynamics and possibility of subsequent collapse for three-dimensional ideal flows. Brachet, M. E.; Meneguzzi, M.; Vincent, A.; Politano, H.; Sulem, P. L. // Physics of Fluids A;Dec92, Vol. 4 Issue 12, p2845 

    Direct numerical simulations of the three-dimensional Euler equations at resolutions up to 2563 for general periodic flows and 8643 for the symmetric Taylor�Green vortex are presented. The spontaneous emergence of flat pancakelike structures that shrink exponentially in time is observed. A...

  • Stabilization and destabilization of channel flow by location of viscosity-stratified fluid layer. Ranganathan, Balaji T.; Govindarajan, Rama // Physics of Fluids;Jan2001, Vol. 13 Issue 1, p1 

    The stability of the channel flow of two fluids of different viscosities with a mixed layer in between is demonstrated to be qualitatively different from both interface dominated flows and stratified flows. More important, this flow displays unexpected changes in stability when the mixed layer...

  • Structural Stability of Turbulent Jets. Farrell, Brian F.; Ioannou, Petros J. // Journal of the Atmospheric Sciences;9/1/2003, Vol. 60 Issue 17, p2101 

    Turbulence in fluids is commonly observed to coexist with relatively large spatial and temporal scale coherent jets. These jets may be steady, vacillate with a definite period, or be irregular. A comprehensive theory for this phenomenon is presented based on the mutual interaction between the...

  • Formation of simple and compound drops in microfluidic devices. Zhou, Chunfeng; Yue, Pengtao; Feng, James J. // Physics of Fluids;Sep2006, Vol. 18 Issue 9, p092105 

    This work is motivated by the recent experimental development of microfluidic flow-focusing devices that produce highly monodisperse simple or compound drops. Using finite elements with adaptive meshing in a diffuse-interface framework, we simulate the breakup of simple and compound jets in...

  • Confined motion of a long bubble through a power-law fluid. Nadim, A.; Borhan, A. // Applied Mathematics Research eXpress;Jan2006, Vol. 2006, p1 

    Understanding the movement of drops and bubbles in microchannels is increasingly important in the design and operation of microfluidic devices that involve two-phase flows. Thus, Bretherton's analysis of the motion of long bubbles in tubes and the associated profile of the wetting film around it...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics