No evidence of the human chorionic gonadotropin-beta gene 5 βV79M polymorphism in Mexican women

Pablo Dominguez-Lopez; Laura Diaz-Cueto; Alfredo Ulloa-Aguirre; Miguel Lopez-Valle; Fabian Arechavaleta-Velasco
December 2008
Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p117
Academic Journal
Abstract  Human chorionic gonadotropin (hCG) is a placental hormone essential for the maintenance of pregnancy. Previous studies have shown a G to A transition in exon 3 of the hCGβ gene 5, which changes the naturally occurring valine to methionine in codon 79. The frequency of this transition varies among different ethnic groups, being high in USA women, and less common, or absent, in various European populations. The purpose of the present study was to determine the frequency of the βV79M allelic variant of the β-subunit of hCG in a Mexican population, and to compare this frequency with those found in other ethnic groups. Placental DNA from 161 pregnant Mexican women was genotyped for the βV79M by polymerase chain reaction (PCR)-restriction fragments length polymorphism analysis. No polymorphic βV79M alleles were identified in the population studied. The allele and genotypic frequencies of βV79M polymorphism in Mexican Mestizo women were significantly different from those reported for the US population, but not from five different European populations. In contrast to what has been found in women from the USA, it seems that the hCGβ V79M polymorphism is absent or extremely rare in Mexican Mestizo women.


Related Articles

  • Relationship between cytokine gene polymorphisms and recurrent spontaneous abortion. Ru-Xin Liu; Ying Wang; Li-Hua Wen // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 6, p9786 

    Recurrent spontaneous abortion (RSA), defined as three or more sequential abortions before the twentieth week of gestation. Some studies have led to the awareness that immunological factors play an important role in establishing a successful pregnancy. The aim of present study was to investigate...

  • Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study. Vidyadhari, M.; Sujatha, M.; Krupa, P.; Jyothy, A.; Nallari, Pratibha; Venkateshwari, A. // Inflammation Research;Dec2015, Vol. 64 Issue 12, p963 

    Objective: The present study is a triad study designed to determine the co-relation of IL-10 −819C/T promoter polymorphism with the risk of spontaneous abortions. Materials: A total of 50 families with spontaneous abortions and 60 families with medically terminated pregnancies were...

  • Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors. Takami, Hirokazu; Fukushima, Shintaro; Fukuoka, Kohei; Suzuki, Tomonari; Yanagisawa, Takaaki; Matsushita, Yuko; Nakamura, Taishi; Arita, Hideyuki; Mukasa, Akitake; Saito, Nobuhito; Kanamori, Masayuki; Kumabe, Toshihiro; Tominaga, Teiji; Kobayashi, Keiichi; Nagane, Motoo; Iuchi, Toshihiko; Tamura, Kaoru; Maehara, Taketoshi; Sugiyama, Kazuhiko; Nakada, Mitsutoshi // Journal of Neuro-Oncology;Aug2015, Vol. 124 Issue 1, p23 

    Human chorionic gonadotropin (hCG) production has been utilized as a diagnostic marker for germinoma with syncytiotrophoblastic giant cells (STGC) and choriocarcinoma. Elevated hCG in germinoma is considered to predict less favorable prognosis, and an intensive treatment strategy may accordingly...

  • Genetic characterization of APOB and D17S5 AFLP loci in a sample form the Basque Country... Alonso, S.; Fernandez-Fernandez, I.; Castro, A.; De Pancorbo, M.M. // Human Biology;Jun98, Vol. 70 Issue 3, p491 

    Examines the variable number of tandem repeats (VNTRs) of amplified fragment length polymorphism (AFLP) loci D17S5 and APOB in 100 unrelated individuals in the Basque Country by polymerase chain reaction (PCR) amplification and polycrylamide gel electrophoresis. Estimation of population...

  • Recurrent early pregnancy loss and endothelial nitric oxide synthase gene polymorphisms. Suryanarayana, Venkata; Rao, Lakshmi; Kanakavalli, Murthy; Padmalatha, Venkata; Deenadayal, Mamata; Singh, Lalji // Archives of Gynecology & Obstetrics;May2006, Vol. 274 Issue 2, p119 

    Objective(s): Studies on the relation between endothelial nitric oxide synthase (eNOS) activity in implantation and maintenance of pregnancy highlights the importance of eNOS gene polymorphisms in recurrent early pregnancy loss (REPL). We investigated the relationship between idiopathic REPL and...

  • StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion. Jahaninejad, Tahere; Ghasemi, Nasrin; Kalantar, Seyyed; Sheikhha, Mohammad; Pashaiefar, Hossein // Journal of Assisted Reproduction & Genetics;Mar2013, Vol. 30 Issue 3, p437 

    Purpose: This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). Method: A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation...

  • The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion. Fang, Yan; Kong, Beihua; Yang, Qifeng; Ma, Daoxin; Qu, Xun // Human Reproduction;May2011, Vol. 26 Issue 5, p1252 

    Background: The interaction between p53 and human double minute 2 (HDM2) plays an important role in apoptosis; therefore, functional polymorphisms in these genes might have adverse effects in early pregnancy. In this study, we investigated whether p53 codon 72 and HDM2 promoter...

  • Association between rs1264457 A/G polymorphism of HLA-E gene and recurrent pregnancy loss. Zarezade Z.; Ashrafzadeh Mehrjardi H. R.; Zaimy M. A.; Ghasemi N. // Iranian Journal of Reproductive Medicine;Apr2015 Supplement, p72 

    Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive miscarriages before twentieth week of pregnancy. The cause of 50% recurrent miscarriages is unexplained. The goal of this research was to investigate the association between RPL and rsl264457 A/G polymorphism of...

  • The changing face of ectopic pregnancy. Mascarenhas, Lawrence; Williamson, John // BMJ: British Medical Journal (International Edition);07/19/97, Vol. 315 Issue 7101, p141 

    Editorial. Discusses various aspects of ectopic pregnancy. Technological advances on the diagnosis and management of an ectopic pregnancy; Clinical presentation of the condition; Abnormalities in pregnancy associated with human chorionic gonadotrophin titres; Diagnosis using laparoscopy.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics