TITLE

No evidence of the human chorionic gonadotropin-beta gene 5 βV79M polymorphism in Mexican women

AUTHOR(S)
Pablo Dominguez-Lopez; Laura Diaz-Cueto; Alfredo Ulloa-Aguirre; Miguel Lopez-Valle; Fabian Arechavaleta-Velasco
PUB. DATE
December 2008
SOURCE
Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p117
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Human chorionic gonadotropin (hCG) is a placental hormone essential for the maintenance of pregnancy. Previous studies have shown a G to A transition in exon 3 of the hCGβ gene 5, which changes the naturally occurring valine to methionine in codon 79. The frequency of this transition varies among different ethnic groups, being high in USA women, and less common, or absent, in various European populations. The purpose of the present study was to determine the frequency of the βV79M allelic variant of the β-subunit of hCG in a Mexican population, and to compare this frequency with those found in other ethnic groups. Placental DNA from 161 pregnant Mexican women was genotyped for the βV79M by polymerase chain reaction (PCR)-restriction fragments length polymorphism analysis. No polymorphic βV79M alleles were identified in the population studied. The allele and genotypic frequencies of βV79M polymorphism in Mexican Mestizo women were significantly different from those reported for the US population, but not from five different European populations. In contrast to what has been found in women from the USA, it seems that the hCGβ V79M polymorphism is absent or extremely rare in Mexican Mestizo women.
ACCESSION #
36232734

 

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