TITLE

Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice

AUTHOR(S)
Ming-Jia Niu; Jin-Kui Yang; Shan-Shan Lin; Xiu-Juan Ji; Li-Min Guo
PUB. DATE
December 2008
SOURCE
Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p56
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  This study aimed to investigate the role of angiotensin-converting enzyme 2 (ACE2) in regulating glucose homeostasis. Immunohistochemistry was used to investigate ACE2 expression in the pancreas. Glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ACE2 knockout (KO) and wild-type (WT) mice. We found that ACE2 was positively expressed in the pancreas. Male ACE2 KO mice displayed a selective decrease in first-phase insulin secretion in response to glucose and a progressive impairment of glucose tolerance compared with age- and sex-matched WT mice. On the other hand, insulin sensitivity of the peripheral tissue in age-matched ACE2 KO and WT mice showed no difference. These findings suggest that ACE2 might play an important role in glucose homeostasis as well as type 2 diabetes.
ACCESSION #
36232729

 

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