Plasma ghrelin levels in males with idiopathic hypogonadotropic hypogonadism

Cevdet Duran; Arif Yonem; Ihsan Ustun; Omer Ozcan; Osman Ipcioglu; Cihat Basekim
December 2008
Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p81
Academic Journal
Abstract  It has recently been shown that ghrelin is a pleitropic modulator with effects on diverse biological functions, such as energy homeostasis and reproduction. In this study, ghrelin levels and its relationship between metabolic and biochemical parameters were investigated in male subjects with idiopathic hypogonadotropic hypogonadism (IHH). Patients in the study were composed of 33 men with IHH, and controls were composed of 36 healthy age-matched men. The patients’ group had significantly higher waist/hip ratio (WHR), and lower testis volume, luteinizing hormone (LH), follicle stimuling hormone (FSH) and total testosterone (TT) levels when compared with controls. Plasma total ghrelin levels were significantly lower in patients than in controls (96.4 ± 29.1 ng/ml vs. 146.1 ± 28.9 ng/ml, P 


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