TITLE

The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population

AUTHOR(S)
Weiqiong Gu; Jie Hong; Yifei Zhang; Zhenni Chi; Yuxia Su
PUB. DATE
December 2008
SOURCE
Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p62
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  TAAAAn polymorphism in sex hormone-binding globulin (SHBG) gene has been found to influence the transcriptional activity of SHBG gene in vitro, and several studies have reported variable associations of this polymorphism with serum SHBG levels in women with polycystic ovary syndrome (PCOS). We have investigated the association of TAAAAn polymorphism with PCOS in 187 women with PCOS and 176 controls; in which five alleles (6–10 repeats) and 13 genotypes were found. None of the TAAAAn alleles or genotypes occurred in significant different frequency in PCOS patients compared with controls. Serum SHBG in the PCOS group was significantly lower than those in controls (33.8 ± 30.2 nmol/l vs. 65.58 ±  31.12 nmol/l; P n (Log10SHBG: 1.46 ± 0.38 and 1.58 ± 0.33, respectively). Similar results were observed for controls (Log10SHBG: 1.79 ± 0.17 and 1.77 ± 0.14, respectively). In contrast, serum SHBG values were negatively associated with body mass index (BMI) and homeostasis model assessment of insulin resistance in the PCOS group (B = −0.285 and −0.264, respectively; P n polymorphism in SHBG gene was not a determinant of PCOS in this population of Chinese women, whereas, serum SHBG was significantly associated with BMI and insulin resistance in these PCOS patients.
ACCESSION #
36232719

 

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