Neurobiological mechanisms in major depressive disorder

aan het Rot, Marije; Mathew, Sanjay J.; Charney, Dennis S.
February 2009
CMAJ: Canadian Medical Association Journal;2/3/2009, Vol. 180 Issue 3, p305
Academic Journal
The article discusses the factors that cause major depressive disorder of neurobiological systems. It examines details related to a patient's genes, childhood and existing stress. It also analyzes the association of neurotrophic factors with brain abnormalities of depressive disorder patients. According to the authors, the prediction of depressive disorder is more visible with the interaction of genes and environment than with environment or genes alone. In addition, brain abnormalities contribute to the reoccurrence of the disease and other chronic disorders. Technological innovations on for depressive disorder treatments are also included.


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