TITLE

Protective effects of antioxidant-fortified diet on renal function and metabolic profile in obese Zucker rat

AUTHOR(S)
Yuriy Slyvka; Sharon Inman; Ramiro Malgor; Edwin Jackson; Jennifer Yee; Olusayo Oshogwemoh; John Adame; Felicia Nowak
PUB. DATE
February 2009
SOURCE
Endocrine (1355008X);Feb2009, Vol. 35 Issue 1, p89
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Oxidative stress contributes to the pathophysiology of type 2 diabetes mellitus and its complications, including nephropathy. The current study was designed to test the hypothesis that a diet fortified with antioxidants would be beneficial to delay or prevent the progression of this disease. Male and female Zucker fa/fa rats were fed a control or an antioxidant (AO)-fortified diet starting at 4 weeks of age. Metabolic parameters, renal function, and renal histopathology were analyzed at 6, 13, and 20 weeks of age. Females on the AO diet had significantly lower blood glucose at 6 and 13 weeks, less severe renal pathology at 20 weeks, and higher glomerular filtration rates (GFR) at 20 weeks than age-matched females on the regular diet (P 
ACCESSION #
36177723

 

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