TITLE

Gene expression test predicts distant recurrence

PUB. DATE
January 2009
SOURCE
British Journal of Hospital Medicine (17508460);Jan2009, Vol. 70 Issue 1, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents the study conducted by researchers from the Royal Marsden Hospital regarding the efficacy of Oncotype DX, a multi-gene expression test, in assessing breast cancer in London, England. They found that when they used Oncotype together with standard measures, it provided a more complete picture of the prognosis, thus doctors can use the information when making chemotherapy treatment decisions.
ACCESSION #
36156992

 

Related Articles

  • Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer. Akslen, L. A.; Straume, O.; Geisler, S.; Sørlie, T.; Chi, J.-T.; Aas, T.; Børresen-Dale, A.-L.; Lønning, P. E. // British Journal of Cancer;6/20/2011, Vol. 105 Issue 1, p9 

    Background:Glomeruloid microvascular proliferation (GMP), a novel histology-based angiogenesis marker, has been associated with decreased survival in several human cancers.Methods:In this study, we evaluated the ability of GMP to predict clinical response to neoadjuvant chemotherapy in a series...

  • Gene Expression Signature and Chemotherapy.  // BioWorld Today;5/14/2012, Vol. 23 Issue 93, Special section p2 

    The article reports on the gene expression profiles that can predict the response of breast cancers to several different types of chemotherapy identified by researchers at the McMaster University.

  • Flow cytometric analysis of CK19 expression in the peripheral blood of breast carcinoma patients: relevance for circulating tumor cell detection. Lili Wang; Yanyan Wang; Yajing Liu; Min Cheng; Xu Wu; Haiming Wei // Journal of Experimental & Clinical Cancer Research (17569966);2009, Vol. 28, p1 

    Background: Immunocytochemistry and RT-PCR have been widely used for the detection of circulating tumor cells in patients with breast cancer but their specificity is limited. Our purpose is to utilize a convenient and specific technology to detect circulating tumor cells in breast cancer...

  • The integrative epigenomic-transcriptomic landscape of ER positive breast cancer. Yang Gao; Jones, Allison; Fasching, Peter A.; Ruebner, Matthias; Beckmann, Matthias W.; Widschwendter, Martin; Teschendorff, Andrew E. // Clinical Epigenetics;12/9/2015, Vol. 7, p1 

    Background: While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events, much less is known about the role of DNA methylation in shaping breast...

  • Genes Set Scene for Metastasis.  // Nutrition Health Review: The Consumer's Medical Journal;2007, Issue 98, p4 

    The article reports that biologists in New York identified a set of genes expressed in human breast cancer cells that worked together to remodel the network of blood vessels at the site of the primary tumor. The researchers identified clinically relevant genes that mediated interactions in the...

  • Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer. Kolacinska, Agnieszka; Fendler, Wojciech; Szemraj, Janusz; Szymanska, Bozena; Borowska-Garganisz, Ewa; Nowik, Magdalena; Chalubinska, Justyna; Kubiak, Robert; Pawlowska, Zofia; Blasinska-Morawiec, Maria; Potemski, Piotr; Jeziorski, Arkadiusz; Morawiec, Zbigniew // Molecular Biology Reports;Jul2012, Vol. 39 Issue 7, p7435 

    Pathologic complete response after neoadjuvant systemic treatment appears to be a valid surrogate for better overall survival in breast cancer patients. Currently, together with standard clinicopathologic assessment, novel molecular biomarkers are being exhaustively tested in order to look into...

  • HER-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination. Tiezzi, Daniel G.; Andrade, Jurandyr M.; Ribeiro-Silva, Alfredo; Zola, Fábio E.; Marana, Heitor R.C.; Tiezzi, Marcelo G. // BMC Cancer;2007, Vol. 7, p36 

    Background: Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of the patients do not benefit from this clinical treatment and, predictive factors of response were not defined yet. This study was designed to evaluate the...

  • Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures. Cheng Fan; Prat, Aleix; Parker, Joel S.; Yufeng Liu; Carey, Lisa A.; Troester, Melissa A.; Perou, Charles M. // BMC Medical Genomics;2011, Vol. 4 Issue 1, p1 

    Background: Multiple breast cancer gene expression profiles have been developed that appear to provide similar abilities to predict outcome and may outperform clinical-pathologic criteria; however, the extent to which seemingly disparate profiles provide additive prognostic information is not...

  • A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy. Hallett, Robin M; Pond, Gregory; Hassell, John A // BMC Medical Genomics;2012, Vol. 5 Issue 1, p16 

    Background: The efficacy of chemotherapy regimens in breast cancer patients is variable and unpredictable. Whether individual patients either achieve long-term remission or suffer recurrence after therapy may be dictated by intrinsic properties of their breast tumors including genetic lesions...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics