TITLE

Hepatitis E, Helicobacter pylori and peptic ulcers in workers exposed to sewage: a prospective cohort study

AUTHOR(S)
Tschopp, A.; Joller, H.; Jeggli, S.; Widmeier, S.; Steffen, R.; Hilfiker, S.; Hotz, P.
PUB. DATE
January 2009
SOURCE
Occupational & Environmental Medicine;Jan2009, Vol. 66 Issue 1, p45
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Workers exposed to sewage may have an increased risk of infection by Helicobacter pylori and hepatitis E virus (HEV). Objectives: To assess the incidence of clinical hepatitis E and peptic ulcers and the seroconversion rate of antibodies to H pylori and HEV in workers with and without sewage exposure. Methods: 332 workers exposed to sewage and a control group of 446 municipal manual workers (61% participation rate) entered a prospective cohort study with clinical examination and determination of antibodies to H pylori and HEV (immunoglobulins G and A or G and M, respectively). Survival curves were examined with log rank tests and Cox regressions. Travelling to endemic areas, socioeconomic level, age, country of childhood, number of siblings, and personal protective equipment were considered as the main confounding factors. Results: Incidence of clinical hepatitis E was not increased in sewage workers. One peptic ulcer and three eradications were recorded in sewage workers compared with no peptic ulcers and 12 eradications in control workers. Incidence rates of approximately 0.01, 0.10, and 0.15 seroconversion/person-year for hepatitis E, H pylori IgG and H pylori IgA, respectively, were found in both exposed and non-exposed workers. Survival curves did not show an increased risk in sewage workers and no association with any exposure indicator was found. Sensitivity analyses did not alter these results. Conclusions: Sewage does not appear to be a source of occupational infection by H pylori or HEV in trained sewage workers with personal protective equipment working in a region with good sanitation.
ACCESSION #
36119399

 

Related Articles

  • Comparison of Rapid Serological Tests (FlexSure HP and QuickVue) with Conventional ELISA for Detection of Helicobacter pylori Infection. Graham, David Y.; Evans Jr., Doyle J.; Peacock, Jeff; Baker, Josefina T.; Schrier, Wayne H. // American Journal of Gastroenterology;May1996, Vol. 91 Issue 5, p942 

    Background: There is a need for accurate and rapid tests for Helicobacter pylori infection especially since the recent National Institutes of Health Consensus Development Conference on H. pylori in peptic ulcer disease charged the medical community with treating H. pylori infection in all...

  • Helicobacter pylori Cytotoxic Genotype Is Associated With Peptic Ulcer and Influences Serology. Navaglia, F.; Basso, D.; Piva, M. G.; Brigato, L.; Stefani, A.; Bò, N. Dal; Di Mario, F.; Rugge, M.; Plebani, M. // American Journal of Gastroenterology;Feb1998, Vol. 93 Issue 2, p227 

    Objective: We studied 146 patients with peptic ulcer disease (n = 72), antral gastritis (n = 58), or duodenitis (n = 16) to ascertain whether the cytotoxic genotype of Helicohacter pylori (Hp) is associated with peptic ulcer disease and/or antral gastritis and whether it influences the...

  • Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls. Lindsetmo, Rolv-Ole; Johnsen, Roar; Eide, Tor Jac; Gutteberg, Tore; Husum, Hanne Haukland; Revhaug, Arthur; Peña, Amado S. // World Journal of Gastroenterology;8/28/2008, Vol. 14 Issue 32, p5039 

    AIM: To estimate the test characteristics of Helicobacter pylori (H pylori)) serology and of C14-urea breath test (C14-UBT)) in two different peptic ulcer populations and in community controls. Second, the aim was to explore the association between the level of H pylori IgG antibodies and...

  • H. pylori, the Most Common Bacterial Infection in Africa: A Random Serological Study. Holcombe, Chris; Omotara, B. A.; Eldridge, D. J.; Jones, D. M. // American Journal of Gastroenterology;Jan1992, Vol. 87 Issue 1, p28 

    This study was carried out to determine the prevalence of antibodies to Helicobacter pylori in northern Nigeria, a region with a low incidence of peptic ulceration. In a random, serological survey of 268 subjects, 228 (85%) of the population studied had IgG antibodies to H. pylori. Fifty-eight...

  • Iga secretory antibodies evaluation in children with chronic gastritis and Helicobacter pylori infection. Ortiz, D.; Porro, M.E. Cavazza; Daud, G.; Daud, N.; Urrestarazu, M.I.; Serrano, N.; Correnti, M.A.; Avila, M.C. // Gut;Sep2002 Supplement 2, Vol. 51, pA43 

    Helicobacter pylori is associated with peptic ulcer disease and represents a risk factor in gastric cancer and maltoma. Secretory IgA, is the predominant gastrointestinal mucosal antibody, with an important effect against different antigens. The objetive of this study was to measure the salival...

  • Seroprevalence of Immunoglobulin G, M, and A Antibodies to Helicobacter pylori in an Unselected Danish Population. Andersen, Leif Percival; Rosenstock, Steffen Jais; Bonnevie, Olaf; Jørgensen, Torben // American Journal of Epidemiology;1996, Vol. 143 Issue 11, p1157 

    The seroprevalences of increased levels of immunoglobulin G (IgG), M (IgM), and A (IgA) antibodies to Helicobacter pylori were assessed by enzyme-linked immunosorbent assay techniques in 3, 589 Danes who participated in a population study in Copenhagen County in 1982. A total of 33.9% of the...

  • Long-term Follow-up and Serological Study after Triple Therapy of Helicobacter pylori-associated Duodenal Ulcer. Wen-Ming Wang; Chang-Yi Chen; Chang-Ming Jan; Li-Tzong Chen; Daw-Shyong Perng; Shiu-Ru Lin; Chiang-Shin Liu // American Journal of Gastroenterology;Oct1994, Vol. 89 Issue 10, p1793 

    Objective: The purpose of this study was to monitor the change of IgG antibodies to Helicobacter pylori during the course of a long-term follow-up after the eradication of H. pylori, as well as to evaluate the efficacy of triple therapy in preventing the recurrence of duodenal ulcer (DU)....

  • Salivary IgG assay to detect Helicobacter pylori infection in an Indian adult population. Krishnaswamy, Ramya Thirumala; David, Chaya Manoranjini; Govindaiah, Savitha; Krishnaprasad, Ramnarayan Belur; Jogigowda, Sanjay Chikkarasinakere // Indian Journal of Dental Research;Sep/Oct2012, Vol. 23 Issue 5, p699 

    Background: Helicobacter pylori infection, the commonest chronic bacterial infection in humans, causes chronic gastritis, peptic ulcer, and possibly gastric carcinoma and lymphoma. Recently, investigators have focused on its role in the development of extra-gastrointestinal diseases with oral...

  • Gastritis/peptic ulcer test.  // MLO: Medical Laboratory Observer;Apr2006, Vol. 38 Issue 4, p34 

    The article evaluates the gastritis or peptic ulcer test GAP-IgA developed by Biomerica Inc. which detects IgA antibodies to Helicobacter pylori in monitoring treatment and determining active infection.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics