Cell biology: Lost nuclei

January 2009
Nature;1/15/2009, Vol. 457 Issue 7227, p239
Academic Journal
The article discusses research conducted by U.S. National Cancer Institute employee Tom Misteli and colleagues on autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD). The disease derives from mutations in the gene LMNA, and the study focused on muscle fibers from mouse models of the disease. Proteins found in the muscles that mediate recruitment of nuclei to the neuromuscular junction do not associate properly with lamin A.


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