Research Capsules

January 2009
Pharmaceutical Representative;Jan2009, Vol. 39 Issue 1, p11
The article discusses studies on several bioactive compounds. A Phase III study found that Entereg from Adolor Corp. and Glaxosmithklin is effective in accelerated gastrointestinal tract recovery and shortened partial bowel resection. A double-blind study revealed the effectiveness UCB's Cimzia in treating patients with rheumatoid arthritis. Study assessed the effectiveness of AstraZeneca PLC's Crestor in reducing the risk of major cardiovascular in men and women with higher C-reactive protein.


Related Articles

  • C-reactive protein: the underlying cause of microvascular dysfunction in rheumatoid arthritis. B. Galarraga; F. Khan; P. Kumar; T. Pullar; J. J. F. Belch // Rheumatology;Dec2008, Vol. 47 Issue 12, p1780 

    Objective. RA is a chronic autoimmune inflammatory condition associated with increased cardiovascular morbidity and mortality. Endothelial dysfunction, a marker of early atherosclerotic disease, occurs in some inflammatory diseases but this relationship has not been previously explored within...

  • Microvascular function is preserved in newly diagnosed rheumatoid arthritis and low systemic inflammatory activity. Eijk, Izhar; Serné, Erik; Dijkmans, Ben; Smulders, Yvo; Nurmohamed, Michael // Clinical Rheumatology;Aug2011, Vol. 30 Issue 8, p1113 

    Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality. Microvascular function has been linked to several risk factors for cardiovascular disease and may be affected in RA. It is, however, presently unknown at what point in the disease course the...

  • Paradoxical Association of C-Reactive Protein with Endothelial Function in Rheumatoid Arthritis. Holmes, Michael V.; Jiang, Benyu; McNeill, Karen; Wong, Melinda; Oakley, Stephen P.; Kirkham, Bruce; Chowienczyk, Phil J. // PLoS ONE;2010, Vol. 5 Issue 4, p1 

    Background: Within the general population, levels of C-reactive protein (CRP) are positively associated with atherosclerotic cardiovascular disease (CVD). Whether CRP is causally implicated in atherogenesis or is the results of atherosclerosis is disputed. A role of CRP to protect...

  • Comparison of Inflammation, Arterial Stiffness and Traditional Cardiovascular Risk Factors between Rheumatoid Arthritis and Inflammatory Bowel Disease. Fenling Fan; Galvin, Abby; Lu Fang; White, David Andrew; Moore, Xiao-lei; Sparrow, Miles; Cicuttini, Flavia; Dart, Anthony Michael // Journal of Inflammation;2014, Vol. 11 Issue 1, p1 

    Background Inflammation plays an important role in the pathogenesis of atherosclerosis. The link between rheumatoid arthritis (RA) and an increased risk of cardiovascular disease and mortality is well established; however, the association between inflammatory bowel disease (IBD) and...

  • Diastolic heart function in RA patients. Wislowska, M.; Jaszczyk, B.; Kochmański, M.; Sypuła, S.; Sztechman, M. // Rheumatology International;Apr2008, Vol. 28 Issue 6, p513 

    The results of some epidemiological studies point to the presence of an increased risk of cardiovascular disease (CVD), particularly atherosclerosis and congestive heart failure (CHF) in rheumatoid arthritis (RA). At least 50% of abnormalities remained asymptomatic. Pathological conditions...

  • Using C-reactive protein in practice. Germino, F. Wilford // Patient Care for the Nurse Practitioner;Apr2002, Vol. 5 Issue 4, p7 

    The article focuses on the use of C-reactive proteins (CRP) in medical practice. It has a precise role in atherogenesis or acute coronary syndromes and is a factor for cardiovascular risk. CRP has been recognized as a marker of inflammation in diseases such as rheumatoid arthritis and vasculitis...

  • Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration. Klimek, Ewa; Skalska, Anna; Kwaśny-Krochin, Beata; Surdacki, Andrzej; Sulicka, Joanna; Korkosz, Mariusz; Fedak, Danuta; Kierzkowska, Izabella; Wizner, Barbara; Grodzicki, Tomasz K. // Mediators of Inflammation;2014, Vol. 2014, p1 

    Objectives. To estimate endothelial dysfunction in patients with rheumatoid arthritis (RA) of short duration in relation to disease activity based on the assessment of 28 joints (DAS28). Methods. We studied 29 patients (22 women, mean age 41 (SD, 9) years) with RA of short duration and 29...

  • Antibodies against oxidized low-density lipoprotein are associated with subclinical atherosclerosis in recent-onset rheumatoid arthritis. Ahmed, Hamada; Youssef, Mahmoud; Mosaad, Youssef // Clinical Rheumatology;Nov2010, Vol. 29 Issue 11, p1237 

    Rheumatoid arthritis (RA) patients have increased mortality largely as a result of cardiovascular diseases (CVD) that cannot be explained by traditional risk factors, suggesting that systemic inflammation may accelerate atherosclerosis. We investigated the presence of subclinical atherosclerosis...

  • Prevalence of atherosclerosis in patients with inactive rheumatoid arthritis. Dehghan, Pooneh; Rajaei, Alireza; Moeineddin, Reza; Alizadeh, Afshin // Clinical Rheumatology;Aug2015, Vol. 34 Issue 8, p1363 

    Patients with rheumatoid arthritis (RA) exhibit higher cardiovascular morbidity and mortality than the general population. The common carotid artery intima-media thickness (CCA-IMT) measured by ultrasound is a validated surrogate marker of atherosclerosis. We studied the prevalence of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics