TITLE

Determination of cefetamet pivoxil in human urine and serum using flow injection chemiluminescence procedure

AUTHOR(S)
Xiaodong Shao; Xin Li; Bei Liu; Zhenghua Song
PUB. DATE
January 2009
SOURCE
Journal of Analytical Chemistry;Jan2009, Vol. 64 Issue 1, p71
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A sensitive chemiluminescence method based on enhancing the effect of cefetamet pivoxil on the chemiluminescent reaction between luminol and dissolved oxygen in a flow injection system was proposed for the determination of cefetamet pivoxil. The increment of the chemiluminescence intensity was proportional to the concentration of cefetamet pivoxil, which yields a calibration graph that is linear over the concentration from 0.4 to 100.0 ng/mL ( r 2 = 0.991) with the detection limit of 0.1 ng/mL (3σ). At a flow rate of 2.0 mL/min complete determination of cefetamet pivoxil, including sampling and washing, could be accomplished in 40 s with the RSD of less than 0.03 ( n = 5). The proposed method was applied successfully to the determination of cefetamet pivoxil in human urine and human serum.
ACCESSION #
36079246

 

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