Congenital Toxoplasmosis and Reinfection during Pregnancy: Case Report, Strain Characterization, Experimental Model of Reinfection, and Review

Elbez-Rubinstein, Annie; Ajzenberg, Daniel; Dardé, Marie-Laure; Cohen, Robert; Dumètre, Aurélien; Yera, Hélène; Gondon, Emmanuelle; Janaud, Jean-Claude; Thulliez, Philippe
January 2009
Journal of Infectious Diseases;1/15/2009, Vol. 199 Issue 2, p280
Academic Journal
We present a case of disseminated congenital toxoplasmosis in a newborn born to a mother who had been immunized against toxoplasmosis before conception. The mother was reinfected, likely by ingestion of imported raw horse meat during pregnancy. This clinical presentation is exceptional in France and raised the possibility of infection by a highly virulent Toxoplasma strain. The strain responsible was isolated from the peripheral blood of the newborn, and when genotyped with microsatellite markers, it exhibited an atypical genotype, one which is very uncommon in Europe but had been described in South America. We tested the hypothesis of a reinfection with a different genotype by using an experimental mouse model, which confirmed that acquired immunity against European Toxoplasma strains may not protect against reinfection by atypical strains acquired during travel outside Europe or by eating imported meat.


Related Articles

  • Extensive clinical, hormonal and genetic screening in a large consecutive series of 46,XY neonates and infants with atypical sexual development. Baetens, Dorien; Mladenov, Wilhelm; Delle Chiaie, Barbara; Menten, Björn; Desloovere, An; Iotova, Violeta; Callewaert, Bert; Van Laecke, Erik; Hoebeke, Piet; De Baere, Elfride; Cools, Martine // Orphanet Journal of Rare Diseases;2014, Vol. 9 Issue 1, p416 

    Background One in 4500 children is born with ambiguous genitalia, milder phenotypes occur in one in 300 newborns. Conventional time-consuming hormonal and genetic work-up provides a genetic diagnosis in around 20-40% of 46,XY cases with ambiguous genitalia. All others remain without a definitive...

  • Screening for microsatellite instability target genes in colorectal cancers. Vilkki, S.; Launonen, V.; Karhu, A.; Sistonen, P.; Västrik, I.; Aaltonen, L.A. // Journal of Medical Genetics;Nov2002, Vol. 39 Issue 11, p785 

    Studies the screening process for microsatellite instability target genes in colorectal cancers. Key issues of interest; Analysis of pertinent topics and relevant issues; Implications on medical genetics.

  • HNPCC Bethesda Guidelines revised.  // Patient Care for the Nurse Practitioner;Apr2004, Vol. 7 Issue 4, p12 

    The article highlights the revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (HNPCC) and microsatellite instability. The revised criteria for testing for HNPCC suggest that tumors from patients with colorectal cancer should be tested for this instability. Subsequent...

  • High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya. Haq, Sameena Z. H.; Abushahama, Muftah S.; Gerwash, Omar; Hughes, Jacqueline M.; Wright, Elizabeth A.; Elmahaishi, Mohamed S.; Zhao-Rong Lun; Thomasson, Denise; Hide, Geoff // Transactions of the Royal Society of Tropical Medicine & Hygiene;Sep2016, Vol. 110 Issue 9, p551 

    Background: Toxoplasma gondii is a parasite that causes significant disease in humans. Toxoplasmosis is normally asymptomatic, unless associated with congenital transmission, or in immunocompromised people. Congenital transmission generally occurs at low frequencies. In this study, we use PCR to...

  • Reverse cascade screening of newborns for hereditary haemochromatosis: a model for other late onset diseases? Cadet, E.; Capron, D.; Gallet, M.; Omanga-Léké, M.-l.; Boutignon, H.; Julier, C.; Robson, K. J. H,.; Rochette, J. // Journal of Medical Genetics;May2005, Vol. 42 Issue 5, p390 

    Background: Genetic testing can determine those at risk for hereditary haemochromatosis (HH) caused by HFE mutations before the onset of symptoms. However, there is no optimum screening strategy, mainly owing to the variable penetrance in those who are homozygous for the HFECys282Tyr (C282Y)...

  • Supporting Family Adaptation to Presymptomatic and "Untreatable" Conditions in an Era of Expanded Newborn Screening. Bailey Jr, Donald B.; Armstrong, F. Daniel; Kemper, Alex R.; Skinner, Debra; Warren, Steven F. // Journal of Pediatric Psychology;Jul2009, Vol. 34 Issue 6, p648 

    Objective As technology advances, newborn screening will be possible for conditions not screened today. With an expansion of screening, strategies will be needed to support family adaptation to unexpected and possibly uncertain genetic information provided shortly after birth. Method Although...

  • Caveats of Genetic Testing. Koppal, Tanuja // Drug Discovery & Development;Jul2004, Vol. 7 Issue 7, p11 

    Editorial. Comments on the rare genetic disorder called glutaric acidemia 1 (GA1) which afflicted two infants born in California. Number of infants affected by GA1; Effect of GA1 on the brain and muscle cells if undetected in the first six to nine months; Need for routine genetic testing.

  • Colloidion Baby. Gupta, Ravinder K.; Sharma, Sunil Dutt; Gupta, Ritu // JK Science;Oct-Dec2009, Vol. 11 Issue 4, p204 

    A two day old male baby, third issue of a second degree consanguineously married couple with clinical features of colloidion baby is being presented. Early recognition of this clinical entity and early institution of appropriate therapy can definitely reduce morbidity and mortality in neonates.

  • What's on the Genetics Test? Walsh, Joseph A. // American Biology Teacher (University of California Press);Jan2012, Vol. 74 Issue 1, p15 

    The prenatal genetic questionnaire given to every pregnant woman provides a useful basis for teaching genetics concepts.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics