TITLE

Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments

AUTHOR(S)
Mwinzi, Pauline N. M.; Ganley-Leal, Lisa; Black, Carla L.; Secor, W. Evan; Karanja, Diana M. S.; Colley, Daniel G.
PUB. DATE
January 2009
SOURCE
Journal of Infectious Diseases;1/15/2009, Vol. 199 Issue 2, p272
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Elevated immunoglobulin E (IgE) levels are often associated with resistance to reinfection in human schistosomiasis. However, Although B cells are the source of schistosome-specific IgE, little is known about B cell subsets or their functions in this infection. We evaluated B cells and their expression of the low-affinity IgE receptor (CD23) in a unique cohort of men occupationally exposed to Schistosoma mansoni and longitudinally followed up through multiple treatments with praziquantel, cures, and reinfections.Methods: Resistance levels were calculated on the basis of documented water exposure and reinfection data over many years. The CD23(+) B cell subset was evaluated in whole blood by flow cytometry. Serum antibody isotype and soluble CD23 (sCD23) concentrations were measured by enzyme-linked immunosorbent assay.Results: Expression of membrane CD23 (mCD23) on B cells correlated with the development of resistance against S. mansoni. Higher levels of plasma sCD23, the cleaved form of mCD23, also correlated with resistance and other markers of resistance to reinfection, such as eosinophilia.Conclusions: CD23 may be involved in the development of resistance to schistosome infection through its role in IgE regulation. Understanding these complex host-parasite interactions may lead to insights into the development, mechanisms, and regulation of resistance to reinfection with S. mansoni.
ACCESSION #
36006757

 

Related Articles

  • Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection. Joseph, Sarah; Jones, Frances M.; Laidlaw, Maureen E.; Mohamed, Gamal; Mawa, Patrice A.; Namujiu, Proscovia B.; Kizza, Moses; Watera, Christine; Whitworth, James A.G.; Dunne, David W.; Elliott, Alison M.; Namujju, Proscovia B // Journal of Infectious Diseases;8/1/2004, Vol. 190 Issue 3, p613 

    We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific...

  • TLR8 deficiency leads to autoimmunity in mice. Demaria, Olivier; Pagni, Philippe P.; Traub, Stephanie; de Gassart, Aude; Branzk, Nora; Murphy, Andrew J.; Valenzuela, David M.; Yancopoulos, George D.; Flavell, Richard A.; Alexopoulou, Lena // Journal of Clinical Investigation;Oct2010, Vol. 120 Issue 10, p3651 

    TLRs play an essential role in the induction of immune responses by detecting conserved molecular products of microorganisms. However, the function of TLR8 is largely unknown. In the current study, we investigated the role of TLR8 signaling in immunity in mice. We found that Tlr8(-/-) DCs...

  • Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. Hyun-Woo Jeong; Un Sil Jeon; Bon-Kyoung Koo; Wan-Young Kim; Sun-Kyoung Im; Juhee Shin, 1,2; Yunje Cho; Jin Kim; Young-Yun Kong; Jeong, Hyun-Woo; Jeon, Un Sil; Koo, Bon-Kyoung; Kim, Wan-Young; Im, Sun-Kyoung; Shin, Juhee; Cho, Yunje; Kim, Jin; Kong, Young-Yun // Journal of Clinical Investigation;Nov2009, Vol. 119 Issue 11, p3290 

    The heterogeneous cellular composition of the mammalian renal collecting duct enables regulation of fluid, electrolytes, and acid-base homeostasis, but the molecular mechanism of its development has yet to be elucidated. The Notch signaling pathway is involved in cell fate determination and has...

  • Testicular Schistosomiasis Mimicking Malignancy in a Child: A Case Report. Ekenze, Sebastian O.; Modekwe, Victor O.; Nzegwu, Martin A.; Ekpemo, Samuel C.; Ezomike, Uchechukwu O. // Journal of Tropical Pediatrics;Aug2015, Vol. 61 Issue 4, p304 

    Schistosomiasis is an important communicable disease in the developing world. However, testicular schistosomiasis is an extremely rare condition. We report a case of testicular schistosomiasis mimicking testicular tumour in a 13 year old who presented with huge unilateral testicular mass. The...

  • Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. McCarthy, Douglas D.; Kujawa, Julie; Wilson, Cheryl; Papandile, Adrian; Poreci, Urjana; Porfilio, Elisa A.; Ward, Lesley; Lawson, Melissa A.E.; Macpherson, Andrew J.; McCoy, Kathy D.; Pei, York; Novak, Lea; Lee, Jeannette Y.; Julian, Bruce A.; Novak, Jan; Ranger, Ann; Gommerman, Jennifer L.; Browning, Jeffrey L. // Journal of Clinical Investigation;Oct2011, Vol. 121 Issue 10, p3991 

    B cell activation factor of the TNF family (BAFF) is a potent B cell survival factor. BAFF overexpressing transgenic mice (BAFF-Tg mice) exhibit features of autoimmune disease, including B cell hyperplasia and hypergammaglobulinemia, and develop fatal nephritis with age. However, basal serum IgA...

  • Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. Goetzl, Edward J.; Rosen, Hugh // Journal of Clinical Investigation;Dec2004, Vol. 114 Issue 11, p1531 

    T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity...

  • Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. Li-Hawkins, Jia; Gåfvels, Mats; Olin, Maria; Lund, Erik G; Andersson, Ulla; Schuster, Gertrud; Björkhem, Ingemar; Russell, David W; Eggertsen, Gosta // Journal of Clinical Investigation;10/1/2002, Vol. 110 Issue 7, p1191 

    Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the...

  • Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. Freitas, Beatriz C. G.; Gereben, Balázs; Castillo^3, Melany; Kalló,, Imre; Zeöld, Anikó; Egri, Péter; Liposits, Zsolt; Zavacki, Ann Marie; Maciel, Rui M. B.; Sungro Jo; Singru, Praful; Sanchez, Edith; Lechan, Ronald M.; Bianco, Antonio C.; Gereben, Balázs; Castillo, Melany; Kalló, Imre; Zeöld, Anikó; Egri, Péter; Jo, Sungro // Journal of Clinical Investigation;Jun2010, Vol. 120 Issue 6, p2206 

    Hypothyroidism in humans is characterized by severe neurological consequences that are often irreversible, highlighting the critical role of thyroid hormone (TH) in the brain. Despite this, not much is known about the signaling pathways that control TH action in the brain. What is known is that...

  • Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. Buettner, Christoph; Patel, Rima; Muse, Evan D.; Bhanot, Sanjay; Monia, Brett P.; Mckay, Rob; Obici, Silvana; Rossetti, Luciano // Journal of Clinical Investigation;May2005, Vol. 115 Issue 5, p1306 

    Insulin exerts its potent effects on hepatic glucose fluxes via direct and indirect mechanisms. Whereas a liver-specific insulin receptor (IR) knockout (LIRKO) mouse exhibits glucose intolerance as well as insulin resistance, it is unclear whether a more acute decrease in the expression of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics