One for all? A viral protein supplants the mRNA cap-binding complex

von der Haar, Tobias
January 2009
EMBO Journal;1/14/2009, Vol. 28 Issue 1, p6
Academic Journal
The article presents a study on the potential of nucleocapsid (N) protein from a species of Hantavirus to replace several host cell translation factors. It shows that recombinantly expressed nucleocapsid or N protein binds to mRNA cap structures and interacts with small ribosomal subunits. Researchers claim that the potential of the protein indicates the evolution of novel strategy from hantaviruses in modulating a multifunctional translation factor.


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