DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma
- Poor Interobserver Agreement in the Distinction of High-Grade Dysplasia and Adenocarcinoma in Pretreatment Barrett's Esophagus Biopsies. Downs-Kelly, Erinn; Mendelin, Joel E.; Bennett, Ana E.; Castilla, Elias; Henricks, Walter H.; Schoenfield, Lynn; Skacel, Marek; Yerian, Lisa; Rice, Thomas W.; Rybicki, Lisa A.; Bronner, Mary P.; Goldblum, John R. // American Journal of Gastroenterology;Sep2008, Vol. 103 Issue 9, p2333
OBJECTIVE: Grading Barrett's dysplasia at the lower end of the metaplasia-dysplasia spectrum (negative, indefinite, and low-grade dysplasia) suffers from poor interobserver agreement, even among gastrointestinal pathologists. Data evaluating interobserver agreement in Barrett's mucosal biopsies...
- Dissection of a complex transcriptional response using genome-wide transcriptional modelling. Barenco, Martino; Brewer, Daniel; Papouli, Efterpi; Tomescu, Daniela; Callard, Robin; Stark, Jaroslav; Hubank, Michael // Molecular Systems Biology;2009, Vol. 5 Issue 1, p327
Modern genomics technologies generate huge data sets creating a demand for systems level, experimentally verified, analysis techniques. We examined the transcriptional response to DNA damage in a human T cell line (MOLT4) using microarrays. By measuring both mRNA accumulation and degradation...
- Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel. Garner, Kristen M.; Eastman, Alan // BMC Cancer;2011, Vol. 11 Issue 1, p206
Background: The Mre11/Rad50/Nbs1 (MRN) complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could...
- miR-24—mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Lal, Ashish; Yunfeng Pan; Navarro, Francisco; Dykxhoorn, Derek M.; Moreau, Lisa; Meire, Eti; Bentwich, Zvi; Lieberman, Judy; Chowdhury, Dipanjan // Nature Structural & Molecular Biology;May2009, Vol. 16 Issue 5, p492
Terminally differentiated cells have a reduced capacity to repair double-stranded breaks, but the molecular mechanism behind this downregulation is unclear. Here we find that miR-24 is upregulated during postmitotic differentiation of hematopoietic cell lines and regulates the histone variant...
- Zebrafish usp39 Mutation Leads to rb1 mRNA Splicing Defect and Pituitary Lineage Expansion. Ríos, Yesenia; Melmed, Shlomo; Shuo Lin; Ning-Ai Liu // PLoS Genetics;Jan2011, Vol. 7 Issue 1, Special section p1
No abstract available.
- Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers. Fernet, M.; Moullan, N.; Lauge, A.; Stoppa-Lyonnet, D.; Hall, J. // British Journal of Cancer;2/23/2004, Vol. 90 Issue 4, p866
It has been estimated that approximately 1% of the general population are ataxia telangiectasia (AT) mutated (ATM) heterozygotes. The ATM protein plays a central role in DNA-damage response pathways; however, the functional consequences of the presence of either heterozygous truncating or...
- Erratum: Novel Probe-Based Confocal Laser Endomicroscopy Criteria and Interobserver Agreement for the Detection of Dysplasia in Barrett's Esophagus. Gaddam, Srinivas; Mathur, Sharad C.; Singh, Mandeep; Arora, Jaya; Wani, Sachin B; Gupta, Neil; Overhiser, Andrew; Rastogi, Amit; Singh, Vikas; Desai, Neel; Hall, Sandra B; Bansal, Ajay; Sharma, Prateek // American Journal of Gastroenterology;Mar2013, Vol. 108 Issue 3, p460
A correction to the article "Novel Probe-Based Confocal Laser Endomicroscopy Criteria and Interobserver Agreement for the Detection of Dysplasia in Barrett's Esophagus" that was published in a previous issue is presented.
- Addendum: BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia. Bennett, Cathy; Moayyedi, Paul; Corley, Douglas A; DeCaestecker, John; Falck-Ytter, Yngve; Falk, Gary; Vakil, Nimish; Sanders, Scott; Vieth, Michael; Inadomi, John; Aldulaimi, David; Ho, Khek-Yu; Odze, Robert; Meltzer, Stephen J; Quigley, Eamonn; Gittens, Stuart; Watson, Peter; Zaninotto, Giovanni; Iyer, Prasad G; Alexandre, Leo // American Journal of Gastroenterology;Jun2015, Vol. 110 Issue 6, p943
A correction to the article "BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia" that was published in the journal in 2015 is presented.
- Management of Barretts oesophagus - Are we there yet? Lambiotte, M. E. J.; Van Rensburg, C. J. // South African Gastroenterology Review;Apr2012, Vol. 10 Issue 1, p19
The article discusses the fundamental issues in the management of Barrett's oesophagus (BO) and to gain insight on the challenges faced by the BO population in South Africa. It mentions that the American Gastroenterology Association (AGA) advocates three pillas of management to combat BO which...