Effects of New Penicillin Susceptibility Breakpoints for Streptococcus pneumoniae -- United States, 2006-2007

Reingold, A.; Gershman, K.; Hadler, J.; Harrison, L.; Glennen, A.; Lesher, L.; Baumbach, J.; Smith, G. L.; Thomas, A.; Schaffner, W. S.; Jorgensen, J.; Beall, B.; Moore, M.; Deutscher, M.; Farley, M. M.; Lynfield, R.; Whitney, C. G.
December 2008
MMWR: Morbidity & Mortality Weekly Report;12/19/2008, Vol. 57 Issue 50, p1353
The article presents an analysis of the effects of penicillin susceptibility breakpoints for Streptococcus pneumoniae in the U.S. from 2006 to 2007. The analysis found that the percentage of invasive pneumococcal disease (IPD) nonmeningitis S. pneumoniae isolates categorized as susceptible and resistant to penicillin changed from 74%, 15.0% and 10.3% under the former breakpoints to 93.2%, 5.6% and 1.2%, respectively, under the new breakpoints. Cases of IPD were identified through the Active Bacterial Core surveillance (ABC) to conduct the analysis.


Related Articles

  • The Trends Of Penicillin Resistant Streptococcus Pneumoniae In A Training Hospital. Oncul, Oral; Erdem, Hakan; Altunay, Husnu; Ozsoy, M. Fevzi; Pahsa, Alaaddin; Cavuslu, Saban // Internet Journal of Infectious Diseases;2003, Vol. 3 Issue 1, p36 

    Objective: Seven-year period of penicillin resistant in pneumococcal strains isolated in a training hospital in Turkey is presented. Methods: Penicillin resistant was investigated in 148 isolates by Mueller Hinton Broth Microdilution test between 1993-1997 (Period I), and by E-test for 101...

  • Isolation of Multiply Antibiotic-resistant Pneumococci.  // Clinical Pediatrics;Apr1986, Vol. 25 Issue 4, p188 

    Discusses the case of a five-year-old female reported with penicillin-resistant type 14 pneumococcal bacterium in the United States. Number of pneumococcal disease in the country caused by fully resistant pneumococci, confirmed by antimicrobial susceptibility testing; Use of a laboratory...

  • Community acquired pneumonia: common causes, treatment and resistance. Banning, Maggie // Nurse Prescribing;Oct2005, Vol. 3 Issue 5, p195 

    In the UK, older people are particularly prone to developing community acquired pneumonia. The most common pathogen is the bacterium Streptococcus pneumoniae. In the environment, S. pneumoniae is a robust microbe that can adapt and survive in hostile conditions and in the human body. Antibiotic...

  • Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model. Temime, L.; Boelle, P. Y.; Courvalin, P.; Guillemot, D. // Emerging Infectious Diseases;Apr2003, Vol. 9 Issue 4, p411 

    Examines the determinants of the difference between Streptococcus pneumoniae and Neisseria meningitidis, and the anticipated trends in meningococcal resistance to penicillin G. Comparison between the mechanisms of Streptococcus pneumoniae and Neisseria meningitidis; Average colonization...

  • Comparative In Vitro Potency of Gemifloxacin and Fluoroquinolones Against Recent European Clinical Isolates from a Global Surveillance Study. Hoban, D. J.; Bouchillon, S. K.; Johnson, J. L.; Zhanel, G. G.; Butler, D. L.; Miller, L. A.; Poupard, J. A. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2001, Vol. 20 Issue 11, p814 

    Gemifloxacin, a new fluoroquinolone with enhanced activity against gram-positive aerobes, was compared to ciprofloxacin, levofloxacin and ofloxacin against 21,464 recent isolates from 16 European countries. Gemifloxacin was the most potent fluoroquinolone against streptococci including...

  • Hospital-reported pneumococcal susceptibility to penicillin. Metlay, Joshua P.; Branas, Charles C.; Fishmant, Nell O.; Fishman, Neil O // Emerging Infectious Diseases;Jan2004, Vol. 10 Issue 1, p54 

    Geographic variation in drug susceptibility among isolates of Streptococcus pneumoniae has influenced national treatment guidelines for community-acquired pneumonia. Whether individual hospital susceptibility data provide reliable and valid information for providers is unclear. We examined the...

  • Prevalence, Determinants, and Molecular Epidemiology of Streptococcus pneumoniae Isolates Colonizing the Nasopharynx of Healthy Children in Rome. Petrosillo, N.; Pantosti, A.; Bordi, E.; Span�, A.; Del Grosso, M.; Tallarida, B.; Ippolito, G. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2002, Vol. 21 Issue 3, p181 

    The aim of this study was to determine the factors favouring Streptococcus pneumoniae nasopharyngeal colonization of healthy children attending daycare centres and to describe the circulation of penicillin-nonsusceptible strains using molecular techniques. A single nasopharyngeal swab was...

  • Homely Respiratory Diseases Revisited. Hickner, John M. // Journal of Family Practice;Feb1998, Vol. 46 Issue 2, p119 

    This article presents the editor's introduction of a series of articles on homely respiratory diseases, published in this issue of "The Journal of Family Practice." The articles represent a response to a challenge to family physician researchers to direct their attention to the homely diseases....

  • Clonal and Capsular Types Decide Whether Pneumococci Will Act as a Primary or Opportunistic Pathogen. Sjöström, K.; Spindler, C.; Ortqvist, A.; Kalin, M.; Sandgren, A.; Kühlmann-Berenzon, S.; Henriques-Normark, B. // Clinical Infectious Diseases;2/15/2006, Vol. 42 Issue 4, p451 

    Background. Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The role of the different capsular and clonal types in invasive disease severity remains to be defined. Methods. Disease severity and disease type were correlated to age, underlying disease, capsular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics