Denmark, Deaunne L.; Milner, Lauren C.; Buck, Kari J.
September 2008
Alcohol Research & Health;2008, Vol. 31 Issue 3, p266
Academic Journal
Behavioral phenotypes (drawal) are typically qthat differ along a specindividual possesses that charmined by multiple genes, as and interactions among genes e.g., drug responses and withuantitative traits—characteristics trum in the extent to which an acteristic. Such traits are deterwell as by environmental factors and environmental factors. The chromosomal regions containing these genes are commonly referred to as quantitative trait loci (QTLs). As described in the preceding article by Hitzemann and colleagues (pp. 270- 271), researchers have developed a variety of strategies to attain greater precision when mapping QTLs (Darvasi 1998; Talbot et al. 1999), which is necessary for unbiased genome-wide approaches such as QTL mapping to be successful in ultimately identifying which gene(s) underlies a QTL's phenotypic influence. Among these, some approaches are clearly superior for fine mapping QTLs associated with behavioral traits. One such strategy employs specially bred animals known as interval-specific congenics (ISCs) (sometimes called small donor segment congenics). This article introduces the use of these animals in mapping QTLs associated with certain responses to alcohol.


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