2008 - Review: An early invasive strategy has similar benefits in men and women with NSTEMI or unstable angina

Granger, Christopher B.
November 2008
ACP Journal Club;11/18/2008, Vol. 149 Issue 5, p5
Academic Journal
The article presents information on a study conducted to find out if an early invasive strategy in patients with non-ST-segment elevation myocardial infarction or unstable angina have similar benefits compared with a conservative strategy in men and women. Studies selected compared an early invasive strategy with a conservative strategy in patients with NSTEMI or unstable angina. The meta-analysis did not find any significant benefit of invasive therapy for death or MI in the overall population.


Related Articles

  • Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies. Wever, Kimberley E.; Hooijmans, Carlijn R.; Riksen, Niels P.; Sterenborg, Thomas B.; Sena, Emily S.; Ritskes-Hoitinga, Merel; Warlé, Michiel C. // PLoS ONE;11/18/2015, Vol. 10 Issue 11, p1 

    Background: Ischemic preconditioning (IPC) of the heart is a protective strategy in which a brief ischemic stimulus immediately before a lethal ischemic episode potently limits infarct size. Although very promising in animal models of myocardial infarction, IPC has not yet been successfully...

  • Early Invasive vs Conservative Treatment Strategies in Women and Men With Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction. O'Donoghue, Michelle; Boden, William E.; Braunwald, Eugene; Cannon, Christopher P.; Clayton, Tim C.; de Winter, Robbert J.; Fox, Keith A. A.; Lagerqvist, Bo; McCullough, Peter A.; Murphy, Sabina A.; Spacek, Rudolf; Swahn, Eva; Wallentin, Lars; Windhausen, Fons; Sabatine, Marc S. // JAMA: Journal of the American Medical Association;7/2/2008, Vol. 300 Issue 1, p71 

    The article presents a meta-analysis of randomized trials comparing the effects and outcomes of an invasive versus a conservative strategy in the treatment of male and female patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). The criteria for data source searching, study...

  • Clopidogrel before percutaneous coronary intervention reduced cardiovascular outcome in ST-elevation myocardial infarction.  // ACP Journal Club;Mar/Apr2006, Vol. 144 Issue 2, p29 

    The article reports that clopidogrel pretreatment before percutaneous coronary intervention (PCI) reduced cardiovascular outcome in ST-elevation myocardial infarction (MI). Patients in the clopidogrel group had lower rates of the composite endpoint from PCI to 30 days after randomization,...

  • Guidelines-based treatments benefit elderly with MI.  // PharmacoEconomics & Outcomes News;6/13/2009, Issue 580, p6 

    The article discusses research being done on the use of guidelines-recommended treatments in the clinical management of myocardial infarction (MI) in elderly patients. It references a study by F. Schiele and colleagues, published in the April 2009 issue of the "European Heart Journal." The study...

  • Health and Economic Benefits of Increased Beta-Blocker Use Following Myocardial Infarction. Phillips, Kathryn A.; Shilipak, Michael G.; Coxson, Pam; Heidenreich, Paul A.; Hunink, M. G. Myriam; Goldman, Paula A.; Williams, Lawrence W.; Weinstein, Milton C.; Goldman, Lee // JAMA: Journal of the American Medical Association;12/6/2000, Vol. 284 Issue 21, p2748 

    Reports on a study of the potential health and economic impact of increased use of beta-blockers in patients who have had myocardial infarction. Design; Setting; Main outcome measures; Results; Conclusion that increased use of beta-blockers after myocardial infarction could lead to gains in...

  • Radial versus femoral access for primary percutaneous coronary intervention: is there a preferred route to the heart? Meier, Pascal; Windecker, Stephan; Lansky, Alexandra J. // Heart;Feb2012, Vol. 98 Issue 4, p269 

    The article discusses a study by M. A. Mamas et al on the influence of access site selection on percutaneous coronary intervention (PCI)-related adverse events in patients presenting with ST elevation myocardial infarction (STEMI). The researchers performed a meta-analysis of nine randomised...

  • Drug-Eluting Stents in Percutaneous Coronary Intervention. Byrne, Robert A.; Sarafoff, Nikolaus; Kastrati, Adnan; Schömig, Albert // Drug Safety;2009, Vol. 32 Issue 9, p749 

    Drug-eluting stent (DES) therapy has represented a very significant milestone in the evolution of percutaneous coronary intervention (PCI) therapy. This review attempts to provide a balanced overview of the unprecedented wealth of data generated on this new technology, by examining the evidence...

  • Drug-eluting stents increased risk for late cardiac death or myocardial infarction more than bare-metal stents. Pfisterer, M.; Brunner-La Rocca, H. P.; Buser, P. T. // ACP Journal Club;May/Jun2007, Vol. 146 Issue 3, p67 

    The article presents a study which examines the effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with coronary artery disease who discontinue anti-platelet therapy. Results revealed that DES lessen the risk of having major cardiac events. It is concluded that...

  • Awake Extracorporeal Membrane Oxygenation (ECMO) as Bridge to Recovery After Left Main Coronary Artery Occlusion: A Promising Concept of Haemodynamic Support in Cardiogenic Shock. Alozie, Anthony; Kische, Stephan; Birken, Thomas; Kaminski, Alexander; Westphal, Bernd; Nöldge-Schomburg, Gabriele; Ince, Hüseyin; Steinhoff, Gustav // Heart, Lung & Circulation;Oct2014, Vol. 23 Issue 10, pe217 

    Cardiogenic shock following acute myocardial infarction is associated with high mortality rate. Different management concepts including fluid management, inotropic support, intra aortic balloon counterpulsation (IABP) and extracorporeal membrane oxygenation (ECMO) mainly in mechanically...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics