TITLE

Multiclass analysis of illicit drugs in plasma and oral fluids by LC-MS/MS

AUTHOR(S)
Sergi, M.; Bafile, E.; Compagnone, D.; Curini, R.; D’Ascenzo, G.; Romolo, F. S.
PUB. DATE
January 2009
SOURCE
Analytical & Bioanalytical Chemistry;Jan2009, Vol. 393 Issue 2, p709
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An analytical procedure for the simultaneous determination in human plasma and oral fluids of several illicit drugs belonging to different chemical and toxicological classes is presented. Amphetamine, methamphetamine, morphine, 6-monoacetylmorphine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, cocaine, benzoylecgonine, tetrahydrocannabinol, carboxytetrahydrocannabinol, ketamine, and phencyclidine have been quantified in real samples using a very rapid sample treatment, basically a protein precipitation. The quantitative analysis was performed by liquid chromatography–tandem mass spectrometry and has been fully validated. All the analytes were detected in positive ionization mode using a TurboIonSpray source, except carboxytetrahydrocannabinol, which was detected in negative ionization mode. The use of a diverter valve between the column and the mass spectrometer allows the preservation of the ion source performances for high-throughput analysis. [Figure not available: see fulltext.]
ACCESSION #
35774236

 

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