TITLE

Influence of obesity on the prevalence and clinical features of asthma

AUTHOR(S)
Boulet, Louis-Philippe
PUB. DATE
December 2008
SOURCE
Clinical & Investigative Medicine;Dec2008, Vol. 31 Issue 6, pE386
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Obesity has been associated with an increased prevalence of asthma and poorer control of this disease. However, the mechanisms by which obesity can influence airway function and make asthma more difficult to control remain uncertain. The physiological changes associated with obesity can contribute to respiratory symptoms and these should be differentiated from those caused by asthma. Obesity can possibly influence the development of asthma through genetic, developmental, hormonal, neurogenic or mechanical influences. Breathing at low lung volumes and changes in the pattern of breathing in obese subjects may alter airway smooth muscle plasticity and airway function. The release by adipocytes of various cytokines and mediators such as Interleukin-6, TNF-α, eotaxin, and leptin, and the reduction of anti-inflammatory adipokines in obese subjects may possibly contribute to the development or increased clinical expression of asthma in promoting airway inflammation. Reduced asthma control and impaired response to asthma therapy have been reported in obese patients. Obesityrelated co-morbidities such as Sleep Apnea and Gastroesophageal reflux may also contribute to this poor control. Weight loss improves asthma control and reduces medication needs. Research is needed to better define the optimal management of obese asthmatic patients.
ACCESSION #
35765187

 

Related Articles

  • Astma i otyÅ‚ość. Kubsik, Beata; Kowalski, Marek L. // Alergia Astma Immunologia;2010, Vol. 15 Issue 1, p19 

    Obesity and asthma prevalence have been increasing in parallel over the last decades. This has led to a hypothesis that these two disorders might be related. Although the exact mechanisms responsible for this relationship remain unknown, numerous published studies suggest that obesity increases...

  • The changing face of asthma in Finland: improved recognition and no further increase in symptoms. Bjerg, Anders // Primary Care Respiratory Journal;Mar2013, Vol. 22 Issue 1, p13 

    The authors reflect on the study by A. Kainu and colleagues, which discusses the impact of age-adjusted prevalence of physician-diagnosed asthma in Helsinki, Finland. They state the comments on the significant increase in physician-diagnosed asthma, along with the prevalence of asthma symptoms...

  • Discussion.  // Respiratory Care;May2008, Vol. 53 Issue 5, p591 

    The article presents a discussion of the paper "Making the Diagnosis of Asthma" by Meredith C. McCormack and Paul L. Enright. According to Enright, the majority of people with intermittent asthma don't actually see a doctor about it and just buy Primatene Mist over the counter to treat their...

  • The added effect of comorbidity on health-related quality of life in patients with asthma. Chen, Wenjia; Lynd, Larry; FitzGerald, J.; Marra, Carlo; Rousseau, Roxanne; Sadatsafavi, Mohsen // Quality of Life Research;Oct2015, Vol. 24 Issue 10, p2507 

    Purpose: To examine the effect of comorbidities on health-related quality of life (HRQoL) and their interaction with asthma control. Methods: In a random sample of adults with asthma, we measured generic (EQ5D) and disease-specific (AQ5D) utility scores. Asthma symptom control was determined...

  • Prevalence of Asthma and Allergic Rhinitis among Adults in Yaounde, Cameroon.  // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Background: Population-based estimates of asthma and allergic rhinitis in sub-Saharan African adults are lacking. We assessed the prevalence and determinants of asthma and allergic rhinitis in urban adult Cameroonians. Methods: A community-based survey was conducted from December 2013 to April...

  • YaÅŸları 6-18 yıl arasında deÄŸiÅŸen çocuklarda obezite, astım ve atopî iliÅŸkisi. CETEMEN, Ayşen; YENİGÜN, Ayşe; ÜNÜVAR, Tolga; GÜLTEKİN, Berna // Asthma Allergy Immunology / Astim Allerji Immunoloji;Dec2012, Vol. 10 Issue 3, p134 

    Objective: There is an increase in the prevalence of asthma, atopy and obesity in recent years. The studies investigating the relationship between these common health problems have shown an increment in the incidence of asthma among obese children. However, literature data regarding the...

  • Asociación de asma, obesidad y enfermedad por reflujo gastroesofágico en niños. Villalpando-Carrión, Salvador; Ura-Hernández, José Pablo; Del Río-Navarro, Blanca Estela; Heller-Rouassant, Solange // Boletin Medico del Hospital Infantil de Mexico (Departamento de ;mar/abr2009, Vol. 66 Issue 2, p153 

    No abstract available.

  • Keeping a pregnant patient's asthma under control. Prasad, Mona; Samuels, Philip // Contemporary OB/GYN;Dec2008, Vol. 53 Issue 12, p28 

    This article discusses asthma during pregnancy and its clinical management. Particular focus is given to the prevalence of asthma among pregnant women, as well as its link with poor pregnancy outcomes. Asthma symptoms include cough, dyspnea, wheezing and chest tightness. There is a need to...

  • Asma. del Río-Navarro, Blanca Estela; Hidalgo-Castro, Emilia María; Luis Sienra-Monge, Juan José // Boletin Medico del Hospital Infantil de Mexico (Departamento de ;ene/feb2009, Vol. 66 Issue 1, p3 

    Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. The chronic inflammation is associated with airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics