TITLE

Chiral separation of raltitrexed by cyclodextrin-modified micellar electrokinetic chromatography

AUTHOR(S)
Yi Liu; Xiaofang Fu; Chao Ma; Jiasheng Zhong; Yiping Liao; Huwei Liu
PUB. DATE
January 2009
SOURCE
Analytical & Bioanalytical Chemistry;Jan2009, Vol. 393 Issue 1, p321
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A rapid and effective method was developed for the chiral separation of raltitrexed (RD) enantiomers by carboxymethyl-beta-cyclodextrin (CM-β-CD)-modified micellar electrokinetic chromatography (MEKC). Optimization of conditions including the type and concentration of the chiral selector, concentration of sodium dodecyl sulfate (SDS), pH and concentration of the background electrolyte (BGE), capillary temperature, and applied voltage was investigated. The enantiomers of raltitrexed could be separated with satisfactory resolution and linear response by using 75 mM Tris-phosphate at pH 8.0 containing 30 mM SDS and 8 mM CM-β-CD as buffer system. Furthermore, the usefulness of this method was demonstrated in a purity test of a real synthetic drug sample. [Figure not available: see fulltext.]
ACCESSION #
35757054

 

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