TITLE

Mathematical modeling of buffers used in myocardial preservation

AUTHOR(S)
Triana, Jonathan R.; Yanagihashi, Mark; Larson, Douglas F.
PUB. DATE
September 2007
SOURCE
Perfusion;Sep2007, Vol. 22 Issue 5, p353
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective. Buffers added to myocardial preservation solutions are considered to be critical for resisting myocardium pH changes from the accumulation of protons (H(sup+]). Our hypothesis is that mathematical modeling of three clinically used buffers will define their individual buffering capacities under simulated clinical conditions. Methods. The buffers, tromethamine (THAM), sodium bicarbonate (HCO[sub3][sup-]), and L-histidine, were compared in terms of their buffering capacity (β) under specific temperatures and concentrations, using a mathematical model. Results. At 37°C, the maximal beta (β[submax]) occurred at pH 7.75 for THAM, pH 6.10 for HCO[sub3[sup-], and pH 5.89 for L-histidine at equimolar concentrations. A decrease in temperature moved β[submax] to a higher pH value for each buffer. At clinical concentrations, L-histidine provided the greatest buffering capacity followed by HCO[sub3[sup-] and THAM, respectively. Discussion. This model permitted comparison of the above buffers under simulated clinical conditions. The assumption was that the magnitude of β[submax] at a given temperature determines which buffer(s) could be most effective for myocardial preservation. Also, the assumption was taken that these buffers are used in a closed system - where there is no continuous blood flow - and that the buffering ability of THAM and L-histidine were not influenced by the accumulation of CO[sub2] as is HCO[sub3[sup-]. THAM and L-histidine were more effective at hypothermic temperatures compared with HCO[sub3[sup-]; however, HCO[sub3[sup-] provided buffering at normothermic temperatures. Through the theoretical considerations of this study, we propose that combining HCO[sub3[sup-] with THAM or L-histidine could be most efficacious for myocardial preservation during open heart surgery or organ transplantation.
ACCESSION #
35748510

 

Related Articles

  • A novel composite coronary bypass graft strategy: the saphenous vein bridge—a pilot study. Tremblay, Jan-Alexis; Stevens, Louis-Mathieu; Chartrand-Lefebvre, Carl; Chandonnet, Martin; Mansour, Samer; Soulez, Gilles; Prieto, Ignacio; Basile, Fadi; Noiseux, Nicolas // European Journal of Cardio-Thoracic Surgery;Oct2013, Vol. 44 Issue 4, pe302 

    OBJECTIVES The aim of this pilot study was to describe and assess the safety of a novel composite graft technique for coronary artery bypass grafting (CABG) surgery. A saphenous vein is grafted to the left anterior descending artery (LAD) and other anterolateral coronary arteries, creating a...

  • Costs and outcomes of acute kidney injury (AKI) following cardiac surgery. Joseph F. Dasta; Sandra L. Kane-Gill; Amy J. Durtschi; Dev S. Pathak; John A. Kellum // Nephrology Dialysis Transplantation;Jun2008, Vol. 23 Issue 6, p1970 

    Background. Acute kidney injury (AKI) is a recognized complication of cardiac surgery; however, the variability in costs and outcomes reported are due, in part, to different criteria for diagnosing and classifying AKI. We determined costs, resource use and mortality rate of patients. We used the...

  • Surgical alternatives to mechanical support. Lewis, M.; Pitt, M.; Bonser, R. // Perfusion;Jul2000, Vol. 15 Issue 4, p379 

    Deals with the indications, potential failures and recent results in 2000 of the currently available surgical alternatives to mechanical support for the treatment of heart failure. Discussion on transplantation and xenotransplantation; Partial left ventricular resection.

  • Young Bronx woman, 19, dispels myths about organ transplant. Egyir, William K. // New York Amsterdam News;4/22/95, Vol. 86 Issue 16, p42 

    Features LaShawn Brown, the patient who underwent organ transplantation in a heart surgery. Complications after the operation; Suggestion of proper dietary habits and medical check-ups for the Blacks; Information about the transplantations; Organ donation considered as a human act.

  • Is it better to use the radial artery as a composite graft? Clinical and angiographic results of aorto-coronary versus Y-graft. Lemma, Massimo; Mangini, Andrea; Gelpi, Guido; Innorta, Andrea; Spina, Amedeo; Antona, Carlo // European Journal of Cardio-Thoracic Surgery;Jul2004, Vol. 26 Issue 1, p110 

    Objective: We sought to evaluate whether the radial artery (RA) provides the same clinical and angiographic results when proximally anastomosed to the aorta or to the left internal thoracic artery (ITA) as a composite Y-graft. Methods: From February 1999 to December 2002, 512 patients underwent...

  • Effect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity. Hunt; Deng, Mario C; De Meester, Johan M J; Smits, Jacqueline M A; Heinecke, Joachim; Scheld, Hans H // BMJ: British Medical Journal (International Edition);09/02/2000, Vol. 321 Issue 7260, p540 

    Objective: To determine whether there is a survival benefit associated with cardiac transplantation in Germany.Design: Prospective observational cohort study.Setting: All 889 adult patients listed for a first heart transplant in Germany in 1997.Main outcome measure: Mortality, stratified by...

  • Current Status of Cardiac Transplantation and Left Ventricular Assist Devices. Frazier, O. H. // Texas Heart Institute Journal;2010, Vol. 37 Issue 3, p319 

    The article discusses the trend in cardiac transplantation and developments in left ventricular assist devices in the U.S. market as of June 2010. The first successful heart transplantation was reportedly performed in April 1968. The author shares that between 1982 and 1992, he performed 138...

  • Sympathetic reinnervation after heart transplantation, assessed by iodine-123 metaiodobenzylguanidine imaging, and heart rate variability Lovric, Silvia Samarin; Avbelj, Viktor; Trobec, Roman; Zorman, Darko; Rakovec, Peter; Hojker, Sergej; Gersak, Borut; Milcinski, Metka // European Journal of Cardio-Thoracic Surgery;Oct2004, Vol. 26 Issue 4, p736 

    Objective: Complete allograft denervation occurs during heart transplantation. Partial ventricular sympathetic reinnervation may develop one year or later after transplantation and can be measured with iodine-123-meta-iodobenziylguanidine (MIBG) uptake. Aim of this study was to assess sinus node...

  • Mid-term results of cardiac autotransplantation as method to treat permanent atrial fibrillation and mitral disease. Troise, Giovanni; Cirillo, Marco; Brunelli, Federico; Tasca, Giordano; Amaducci, Andrea; Mhagna, Zen; Tomba, Margherita Dalla; Quaini, Eugenio // European Journal of Cardio-Thoracic Surgery;Jun2004, Vol. 25 Issue 6, p1025 

    Objectives: The results of current surgical options for the treatment of permanent atrial fibrillation (AF) associated with mitral surgery are widely different, particularly in very enlarged left atria. The aim of this study was to assess the mid-term efficacy of cardiac autotransplantation for...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics