TITLE

Evaluation of oxygenators and centrifugal pumps for long-term pediatric extracorporeal membrane oxygenation

AUTHOR(S)
Thiara, A. P. S.; Hoel, T. N.; Kristiansen, F.; Karlsen, H. M.; Fiane, A. E.; Svennevig, J. L.
PUB. DATE
September 2007
SOURCE
Perfusion;Sep2007, Vol. 22 Issue 5, p323
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Two extracorporeal membrane oxygenation (ECMO) circuits for children under 10 kg were evaluated and compared for plasma leakage, hemolysis, blood transfusions, and durability. Methods: Group A (n = 20) was supported by ECMO circuits with the Minimax oxygenator and the Biomedicus centrifugal pump. Group B (n = 10) was supported by ECMO circuits with the Lilliput 2 ECMO oxygenator and the Rotaflow centrifugal pump. Results: ECMO circuit durability, as measured by oxygenator lifespan, was significantly better in Group B than in Group A (p = 0.04). There was significantly lower hemolysis, measured by plasma free hemoglobin, in Group B (p = 0.019), and patients in Group B had significantly less need for antithrombin III transfusion (p = 0.004). No plasma leakage was observed in Group B oxygenators, but plasma leakage was observed in all Group A oxygenators. Conclusion: The combination of a Rotaflow centrifugal pump and Lilliput 2 ECMO oxygenator in pediatric ECMO circuits improved durability and reduced circuit-induced hemolysis. This improvement may be due to the low priming volume, the oxygenator's plasma leakage resistance, the suspended rotor of the centrifugal pump, or a combination of these factors.
ACCESSION #
35748505

 

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