Plasma deuterium oxide accumulation following ingestion of different carbohydrate beverages

Currell, Kevin; Urch, Joanna; Cerri, Erika; Jentjens, Roy L. P.; Blannin, Andy K.; Jeukendrup, Asker E.
December 2008
Applied Physiology, Nutrition & Metabolism;Dec2008, Vol. 33 Issue 6, p1067
Academic Journal
Optimal fluid delivery from carbohydrate solutions such as oral rehydration solutions or sports drinks is essential. The aim of the study was to investigate whether a beverage containing glucose and fructose would result in greater fluid delivery than a beverage containing glucose alone. Six male subjects were recruited (average age (±SD): 22 ± 2 y). Subjects entered the laboratory between 0700h and 0900h after an overnight fast. A 600 mL bolus of 1 of the 3 experimental beverages was then given. The experimental beverages were water (W), 75 g glucose (G), or 50 g glucose and 25 g fructose (GF); each beverage also contained 3.00 g of D2O. Following administration of the experimental beverage subjects remained in a seated position for 180 min. Blood and saliva samples were then taken every 5 min in the first hour and every 15 min thereafter. Plasma and saliva samples were analyzed for deuterium enrichment by isotope ratio mass spectrometry. Deuterium oxide enrichments were compared using a 2-way repeated measures analysis of variance. The water trial (33 ± 3 min) showed a significantly shorter time to peak than either G (82 ± 40 min) or GF (59 ± 25 min), but the difference between G and GF did not reach statistical significance. There was a significantly greater AUC for GF (55 673 ± 10 020 δ‰ vs. Vienna Standard Mean Ocean Water (VSMOW).180min) and W (60 497 ± 9864 δ‰ vs. VSMOW.180min) compared with G (46 290 ± 9622 δ‰ vs. VSMOW.180min); W and GF were not significantly different from each other. These data suggest that a 12.5% carbohydrate beverage containing glucose and fructose results in more rapid fluid delivery in the first 75 min than a beverage containing glucose alone.


Related Articles

  • Sports Drinks: Get All the Benefits, With Less Expense. Smith, Russell // Bulverde Standard (Canyon Lake, TX);3/4/2009, Vol. 26 Issue 9, p8 

    The article presents some ideas for getting the rehydration benefits associated with sports drinks for less money.

  • Fear of venepuncture as a barrier to testing for blood-borne infection and use of an oral fluid test as an alternative to venepuncture in a genitourinary medicine clinic. McClean, A. J.; Taylor, A. J.; Mortimer, A. M. // Sexually Transmitted Infections;Feb2007, Vol. 83 Issue 1, p66 

    Objective: A survey of 505 consecutive patients attending a UK genitourinary medicine clinic (GUM) included a psychometric tool to compute a fear of venepuncture (FOV) score, responses to the offer of venepuncture and to alternative testing. Method: An oral fluid test (OFT) was available to test...

  • Gleukos Performance Beverage-Lemon;Punch.  // MarketWatch: Drinks;Dec2005, Vol. 4 Issue 12, p4 

    The article evaluates the Gleukos Performance Beverage-Lemon, Punch drink by Gleukos Inc. and offers information on it being a revolution in energy replenishment and hydration.

  • Effect of two sports drinks on urinary lithogenicity. Goodman, Jeffrey W.; Asplin, John R.; Goldfarb, David S. // Urological Research;Feb2009, Vol. 37 Issue 1, p41 

    The effect of commercial oral rehydration solutions (“sports drinks”) relative to water on risk of nephrolithiasis has not been studied previously. We studied the effect of two sports drinks, Performance (Shaklee Corp., Pleasanton, CA, USA) and Gatorade (Gatorade, Chicago, IL, USA)...

  • Rehydrate in a flash.  // Australian Parents;Feb/Mar2003, p46 

    Provides information on HYDRAlyte, a ready-to-drink oral rehydration solution for mild to moderate dehydration. Contents of the drink.

  • Acute biochemical responses to moderate beer drinking. Gill, G.V.; Baylis, P.H.; Flear, C.T.G.; Skillen, A.W.; Diggle, P.H. // British Medical Journal (Clinical Research Edition);12/18/1982, Vol. 285 Issue 6357, p1770 

    Investigates the biochemical responses to moderate beer drinking. Rise in plasma mobility; Increase in free water clearance; Decrease im plasma concentration.

  • Secretory proteins in the saliva of children. Sivakumar, Thiruvanamalai; Hand, Arthur R.; Mednieks, Maija // Journal of Oral Science;Dec2009, Vol. 51 Issue 4, p573 

    The protein composition of oral fluid is modulated by environmental factors and physiological states, i.e. chemical, mechanical and pharmacologic stimuli, pathologic conditions, and psychological stress. Secretory protein concentrations in samples of whole saliva (WS) from children were measured...

  • Effect of beverage glucose and sodium content on fluid delivery. Jeukendrup, Asker E.; Currell, Kevin; Clarke, Juliette; Cole, Johnny; Blannin, Andrew K. // Nutrition & Metabolism;2009, Vol. 6, p1 

    Background: Rapid fluid delivery from ingested beverages is the goal of oral rehydration solutions (ORS) and sports drinks. Objective: The aim of the present study was to investigate the effects of increasing carbohydrate and sodium content upon fluid delivery using a deuterium oxide (D2O)...

  • An amino acid-electrolyte beverage may increase cellular rehydration relative to carbohydrate-electrolyte and flavored water beverages. Chih-Yin Tai; Joy, Jordan M.; Falcone, Paul H.; Carson, Laura R.; Mosman, Matt M.; Straight, Justen L.; Oury, Susie L.; Mendez Jr., Carlos; Loveridge, Nick J.; Kim, Michael P.; Moon, Jordan R. // Nutrition Journal;2014, Vol. 13, p63 

    Background In cases of dehydration exceeding a 2% loss of body weight, athletic performance can be significantly compromised. Carbohydrate and/or electrolyte containing beverages have been effective for rehydration and recovery of performance, yet amino acid containing beverages remain...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics