Pathological lesions in colonic biopsies during Parkinson's disease

Lebouvier, T; Chaumette, T; Damier, P; Coron, E; Touchefeu, Y; Vrignaud, S; Naveilhan, P; GaImiche, J-P; des Varannes, S Bruley; Derkinderen, P; Neunlist, M
December 2008
Gut;Dec2008, Vol. 57 Issue 12, p1741
Academic Journal
The article presents an analysis of the enteric nervous system (ENS) of patients with Parkinson's Disease (PD). Routine colonic biopsies in five PD patients were performed. Immunohistochemical studies showed that 4 out of 5 PD patients had phospho-α-synuclein-IR neurites, which are absent in both control and constipated patients. The author concludes that routine colonic biopsies can be used to study the submucosal plexus of the ENS.


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