TITLE

Pathological lesions in colonic biopsies during Parkinson's disease

AUTHOR(S)
Lebouvier, T; Chaumette, T; Damier, P; Coron, E; Touchefeu, Y; Vrignaud, S; Naveilhan, P; GaImiche, J-P; des Varannes, S Bruley; Derkinderen, P; Neunlist, M
PUB. DATE
December 2008
SOURCE
Gut;Dec2008, Vol. 57 Issue 12, p1741
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents an analysis of the enteric nervous system (ENS) of patients with Parkinson's Disease (PD). Routine colonic biopsies in five PD patients were performed. Immunohistochemical studies showed that 4 out of 5 PD patients had phospho-α-synuclein-IR neurites, which are absent in both control and constipated patients. The author concludes that routine colonic biopsies can be used to study the submucosal plexus of the ENS.
ACCESSION #
35718748

 

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