Urinary levels of endothelin-1 in type 2 diabetes mellitus patients: a non-defined marker of early renal damage

Macías-Cervantes, Maciste H.; Kornhauser, Carlos; Pérez-Luque, Elva L.; Garay-Sevilla, M. Eugenia; Rivera-Cisneros, Antonio E.
January 2008
Revista Mexicana de Patologia Clinica;ene-mar2008, Vol. 55 Issue 1, p42
Academic Journal
Background/Aims: As urinary endothelin-1 excretion (UET-1) is greater in patients with any cause of renal disease when compared to normal subjects, it eventually may be considered as a renal disease marker. Methods: We compared the UET-1 excretion in 67 type 2 diabetes mellitus patients (DM2) with and without hypertension (HT), and with and without microalbuminuria (MA). And in 14 healthy subjects as a control. MA and UET-1 were assessed in 24 h urine, and the difference between groups was tested by ANOVA. The association between UET-1 and variables like evolution time, metabolic control, and renal disease was tested by a multiple correlation test. Results: UET-1 was greater in the group of diabetics without MA when compared to the group of hypertensive diabetics with MA (p < 0.04). UET-1 was different between the control group and the group of diabetics without HT. Conclusion: In our study, the ET-1 excretion tends to be greater in diabetic patients without hypertension as compared with diabetic hypertensive patients. We think the role played by the urinary ET-1 excretion on renal pathophysiology should be clarified in glomerular and proximal tubule pathology.


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