TITLE

Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have not

AUTHOR(S)
Puri, Basant K.; Counsell, Serena J.; Saeed, Nadeem; Bustos, Marcelo G.; Treasaden, Ian H.; Bydder, Graeme M.
PUB. DATE
January 2008
SOURCE
BMC Psychiatry;2008 Supplement 1, Vol. 8, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The aim was to carry out the first voxel-based morphometry study of grey matter changes in the whole brain in schizophrenia associated with a history of seriously and violently offending. Methods: Structural cerebral magnetic resonance imaging scans of 26 patients with schizophrenia were analyzed using voxel-based morphometry: 13 of the patients had seriously and violently offended directly as a result of schizophrenia prior to admission, the offences consisting of homicide, attempted murder or wounding with intent to cause grievous bodily harm; the other 13 patients did not have a history of violence. There was no history of comorbid psychoactive substance misuse disorder in any of the patients. Voxelwise generalized linear modelling was applied to the processed magnetic resonance data using permutation-based non-parametric testing, forming clusters at t > 2.3 and testing clusters for significance at p < 0.05, corrected for multiple comparisons across space. Results: The two groups of patients were matched with respect to age, gender and duration of illness, but the group with a history of serious violence was on average receiving a higher dose of antipsychotic medication than the group without a history of violence. There were local regions of reduced grey matter volume in the schizophrenia patient group with a history of serious and violent offending, compared with the schizophrenia patient group without such a history. Significant voxels (p < 0.05, corrected for multiple comparisons) were noted bilaterally in the cerebellum and in BA 39 and 40. Conclusion: These regions are important in verbal working memory. The cerebellum may integrate inputs from ventrolateral prefrontal cortex and parietal regions, providing a corrective signal that refines the process of rehearing the contents of the phonological store. A strong connection has been hypothesized between the supramarginal region corresponding to BA 39/40 and Broca's area, which may correspond largely to the arcuate fasciculus, with the connectional pattern of the language regions of this model fitting the network of parietotemporal-prefrontal connections that participate in working memory. Therefore our results point to the possibility of an abnormality in neural circuits involved in verbal working memory in this group of patients.
ACCESSION #
35702852

 

Related Articles

  • Functional Connectivity in MRI Is Driven by Spontaneous BOLD Events. Allan, Thomas W.; Francis, Susan T.; Caballero-Gaudes, Cesar; Morris, Peter G.; Liddle, Elizabeth B.; Liddle, Peter F.; Brookes, Matthew J.; Gowland, Penny A. // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Functional brain signals are frequently decomposed into a relatively small set of large scale, distributed cortical networks that are associated with different cognitive functions. It is generally assumed that the connectivity of these networks is static in time and constant over the whole...

  • Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study. Bisecco, Alvino; Altieri, Manuela; Santangelo, Gabriella; Di Nardo, Federica; Docimo, Renato; Caiazzo, Giuseppina; Capuano, Rocco; Pappacena, Simona; d'Ambrosio, Alessandro; Bonavita, Simona; Trojsi, Francesca; Cirillo, Mario; Esposito, Fabrizio; Tedeschi, Gioacchino; Gallo, Antonio // Frontiers in Behavioral Neuroscience;2/6/2020, p1 

    Social cognition includes mental operations essential for functional social interactions, and several studies revealed an impairment of social cognition abilities in patients with Multiple Sclerosis (MS). These deficits have been related to global and focal gray matter atrophy as well as...

  • Shifted Coupling of EEG Driving Frequencies and fMRI Resting State Networks in Schizophrenia Spectrum Disorders. Razavi, Nadja; Jann, Kay; Koenig, Thomas; Kottlow, Mara; Hauf, Martinus; Strik, Werner; Dierks, Thomas // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Introduction: The cerebral resting state in schizophrenia is altered, as has been demonstrated separately by electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) resting state networks (RSNs). Previous simultaneous EEG/fMRI findings in healthy controls suggest that a...

  • Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study. Nenadic, Igor; Smesny, Stefan; Schlösser, Ralf G. M.; Sauer, Heinrich; Gaser, Christian; Schlösser, Ralf G M // British Journal of Psychiatry;May2010, Vol. 196 Issue 5, p412 

    We applied voxel-based morphometry to high-resolution magnetic resonance images of 99 participants with schizophrenia. Voxel-wise correlations with a score of auditory hallucination severity identified areas in the left and right superior temporal cortex (including Heschl's gyrus), left...

  • Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study. Jiang, Sisi; Yan, Hao; Chen, Qiang; Tian, Lin; Lu, Tianlan; Tan, Hao-Yang; Yan, Jun; Zhang, Dai // PLoS ONE;8/13/2015, Vol. 10 Issue 8, p1 

    Background: It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many...

  • Olanzapine Increases Grey and White Matter Volumes in the Caudate Nucleus of Patients with Schizophrenia. Okugawa, Gaku; Nobuhara, Kenji; Takase, Katsunori; Saito, Yukiko; Yoshimura, Masafumi; Kinoshita, Toshihiko // Neuropsychobiology;2007, Vol. 55 Issue 1, p43 

    There are inconsistent reports regarding the caudate nucleus volume in patients with schizophrenia compared with healthy subjects. The reason for this is that neuroleptic medication may affect the volume of the caudate nucleus in schizophrenic patients. To clarify which antipsychotic medication...

  • The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study. Falkai, Peter; Malchow, Berend; Wobrock, Thomas; Gruber, Oliver; Schmitt, Andrea; Honer, William; Pajonk, Frank-Gerald; Sun, Frank; Cannon, Tyrone // European Archives of Psychiatry & Clinical Neuroscience;Sep2013, Vol. 263 Issue 6, p469 

    Via influencing brain plasticity, aerobic exercise could contribute to the treatment of schizophrenia patients. As previously shown, physical exercise increases hippocampus volume and improves short-term memory. We now investigated gray matter density and brain surface expansion in this sample...

  • An fMRI Investigation of Analogical Mapping in Metaphor Comprehension: The Influence of Context and Individual Cognitive Capacities on Processing Demands. Prat, Chantel S.; Mason, Robert A.; Just, Marcel Adam // Journal of Experimental Psychology. Learning, Memory & Cognition;Mar2012, Vol. 38 Issue 2, p282 

    This study used fMRI to investigate the neural correlates of analogical mapping during metaphor comprehension, with a focus on dynamic configuration of neural networks with changing processing demands and individual abilities. Participants with varying vocabulary sizes and working memory...

  • Statistical network analysis for functional MRI: summary networks and group comparisons. Ginestet, Cedric E.; Fournel, Arnaud P.; Simmons, Andrew // Frontiers in Computational Neuroscience;May2014, Vol. 8, p1 

    Comparing networks in neuroscience is hard, because the topological properties of a given network are necessarily dependent on the number of edges in that network. This problem arises in the analysis of both weighted and unweighted networks. The term density is often used in this context, in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics