TITLE

The use of artificial neural networks to study fatty acids in neuropsychiatric disorders

AUTHOR(S)
Cocchi, Massimo; Tonello, Lucio; Tsaluchidu, Sofia; Puri, Basant K.
PUB. DATE
January 2008
SOURCE
BMC Psychiatry;2008 Supplement 1, Vol. 8, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The range of the fatty acids has been largely investigated in the plasma and erythrocytes of patients suffering from neuropsychiatric disorders. In this paper we investigate, for the first time, whether the study of the platelet fatty acids from such patients may be facilitated by means of artificial neural networks. Methods: Venous blood samples were taken from 84 patients with a DSM-IV-TR diagnosis of major depressive disorder and from 60 normal control subjects without a history of clinical depression. Platelet levels of the following 11 fatty acids were analyzed using one-way analysis of variance: C14:0, C16:0, C16:1, C18:0, C18:1 n-9, C18:1 n-7, C18:2 n-6, C18:3 n-3, C20:3 n-3, C20:4 n-6 and C22:6 n-3. The results were then entered into a wide variety of different artificial neural networks. Results: All the artificial neural networks tested gave essentially the same result. However, one type of artificial neural network, the self-organizing map, gave superior information by allowing the results to be described in a two-dimensional plane with potentially informative border areas. A series of repeated and independent self-organizing map simulations, with the input parameters being changed each time, led to the finding that the best discriminant map was that obtained by inclusion of just three fatty acids. Conclusion: Our results confirm that artificial neural networks may be used to analyze platelet fatty acids in neuropsychiatric disorder. Furthermore, they show that the self-organizing map, an unsupervised competitive-learning network algorithm which forms a nonlinear projection of a highdimensional data manifold on a regular, low-dimensional grid, is an optimal type of artificial neural network to use for this task.
ACCESSION #
35702849

 

Related Articles

  • Essential fatty acids and the brain. Haag, Marianne // Canadian Journal of Psychiatry;Apr2003, Vol. 48 Issue 3, p195 

    Objective: To review the role of essential fatty acids in brain membrane function and in the genesis of psychiatric disease.Method: Medline databases were searched for published articles with links among the following key words: essential fatty acids, omega-3 fatty...

  • FATS FOR MENTAL HEALTH. SerVaas, Cory; Perry, Patrick // Saturday Evening Post;Mar/Apr99, Vol. 271 Issue 2, p36 

    Provides information on essential fatty acids beneficial for the brain. Food sources rich in omega-3 fatty acids; Physiological role of omega-6 fatty acids; Importance of fish diet on mental health.

  • Dietary Manipulations of Polyunsaturated Fatty Acids, the Precursors of Endocannabinoids, and its Implications in Human Health and Disease. Repossi, G.; Dain, A.; Eynard, A. R. // Current Nutrition & Food Science;2009, Vol. 5 Issue 2, p112 

    The essential PUFAs (polyunsaturated fatty acids) serve as precursors of several bioactive lipids molecules including the endocannabinoids (ECS). This article reviews the components of the endocannabinoid system, and their functions. Furthermore, a brief overview on the relationship of this...

  • Evaluation and validation of a measure profiling needs and problems of psychiatric patients in the community: a Malaysian study. Cheah, Y.-C.; Parker, G.; Roy, K. // Social Psychiatry & Psychiatric Epidemiology;2000, Vol. 35 Issue 4, p170 

    Abstract Background: The Profile of Community Psychiatry Clients (PCPC) was developed in a Sydneybased sample of those with a mental illness as a 35-item measure of likely need for service recognition, review and possible assistance. Methods: This study has three principal objectives. Firstly,...

  • Mental Health: Diffuse, Confuse and Refuse. PALMER, VICTORIA J. // Social Alternatives;2008 Fourth Quarter, Vol. 27 Issue 4, p3 

    The article discusses various reports published within the issue, including one by Naimet on living with a family member with a mental illness, one by Brown and Lawn about working with people affected by mental illnesses, and one by Morrison about working with survivors of mental illness.

  • Reforming the 1983 Mental Health Act. Hope, Tony // Journal of Medical Ethics;Oct99, Vol. 25 Issue 5, p363 

    Offers views on reforming the 1983 Mental Health Act. Different ways people with mental disorder are discriminated; Provision of the act; Arguments on the act.

  • onomatomania.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1631 

    A definition of the term "onomatomania" which refers to a mental illness is presented.

  • TIME TREK.  // Current Events;2/2/2001, Vol. 100 Issue 17, p2 

    Presents a timeline the chronicles that medical community's treatment of mental illness. Ancient Greek physician Hippocrates' view of mental illness as the result of disease or an imbalance in bodily fluids; Labeling of mentally ill people as 'witches' during the 16th and 17th centuries.

  • CAN YOU HEAR ME THINKING? Bellamy, James D. // Psychiatric Rehabilitation Journal;Summer2000, Vol. 24 Issue 1, p73 

    Presents a patient's account of his psychological illness. Symptoms developed for months; Crises encountered during last three years at school; Experiences in hearing voices and visual hallucinations; Realization and acceptance of his condition.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics