Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia

Deng, Xiangdong; Sagata, Noriaki; Takeuchi, Naoko; Tanaka, Masami; Ninomiya, Hideaki; Iwata, Nakao; Ozaki, Norio; Shibata, Hiroki; Fukumaki, Yasuyuki
January 2008
BMC Psychiatry;2008, Vol. 8, Special section p1
Academic Journal
Background: Based on the glutamatergic dysfunction hypothesis for schizophrenia pathogenesis, we have been performing systematic association studies of schizophrenia with the genes involved in glutametergic transmission. We report here association studies of schizophrenia with SLC1A4, SLC1A5 encoding neutral amino acid transporters ASCT1, ASCT2, and SLC6A5, SLC6A9 encoding glycine transporters GLYT2, GLYT1, respectively. Methods: We initially tested the association of 21 single nucleotide polymorphisms (SNPs) distributed in the four gene regions with schizophrenia using 100 Japanese cases-control pairs and examined allele, genotype and haplotype association with schizophrenia. The observed nominal significance were examined in the full-size samples (400 cases and 420 controls). Results: We observed nominally significant single-marker associations with schizophrenia in SNP2 (P = 0.021) and SNP3 (P = 0.029) of SLC1A4, SNP1 (P = 0.009) and SNP2 (P = 0.022) of SLC6A5. We also observed nominally significant haplotype associations with schizophrenia in the combinations of SNP2-SNP7 (P = 0.037) of SLC1A4 and SNP1-SNP4 (P = 0.043) of SLC6A5. We examined all of the nominal significance in the Full-size Sample Set, except one haplotype with insufficient LD. The significant association of SNP1 of SLC6A5 with schizophrenia was confirmed in the Full-size Sample Set (P = 0.018). Conclusion: We concluded that at least one susceptibility locus for schizophrenia may be located within or nearby SLC6A5, whereas SLC1A4, SLC1A5 and SLC6A9 are unlikely to be major susceptibility genes for schizophrenia in the Japanese population.


Related Articles

  • Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia. Xiangdong Deng; Shibata, Hiroki; Ninomiya, Hideaki; Tashiro, Nobutada; Iwata, Nakao; Ozaki, Norio; Fukumaki, Yasuyuki // BMC Psychiatry;2004, Vol. 4, p1 

    Background: The glutamatergic dysfunction hypothesis of schizophrenia suggests that genes involved in glutametergic transmission are candidates for schizophrenic susceptibility genes. We have been performing systematic association studies of schizophrenia with the glutamate receptor and...

  • Comparison of four flow cytometric SNP detection assays and their use in plant improvement. Lee, S.-H.; Walker, D.; Cregan, P.; Boerma, H. // Theoretical & Applied Genetics;Dec2004, Vol. 110 Issue 1, p167 

    Single nucleotide polymorphisms (SNPs) are attractive DNA markers due to their abundance and potential for use in automated high-throughput genotyping. Numerous SNP genotyping assays have been developed, but it is unclear which assays are best suited and most efficient for various types of plant...

  • Corrigendum: Allosteric potentiation of glycine receptor chloride currents by glutamate. Liu, Jun; Wu, Dong Chuan; Wang, Yu Tian // Nature Neuroscience;Sep2011, Vol. 14 Issue 9, p1217 

    A correction to the article "Allosteric potentiation of glycine receptor chloride currents by glutamate" that was published in the September 12, 2010 issue is presented.

  • No relationship between 2′,3′-cyclic nucleotide 3′-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis. Ronglin Che; Wei Tang; Jing Zhang; Zhiyun Wei; Zhao Zhang; Ke Huang; Xinzhi Zhao; Jianjun Gao; Guoquan Zhou; Peirong Huang; Lin He; Yongyong Shi // BMC Medical Genetics;2009, Vol. 10, Special section p1 

    Background: 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP), one of the promising candidate genes for schizophrenia, plays a key part in the oligodendrocyte function and in myelination. The present study aims to investigate the relationship between CNP and schizophrenia in the Chinese...

  • Effect of Serotonin-Related Gene Polymorphisms on Pathogenesis and Treatment Response in Korean Schizophrenic Patients. Yong-Ku Kim; Ho-Kyoung Yoon // Behavior Genetics;Sep2011, Vol. 41 Issue 5, p709 

    Serotonin has been implicated in the pathophysiology of several psychiatric disorders including schizophrenia. Serotonergic system-related genes may be good candidates in investigating the genetic basis of schizophrenia. We aimed to investigate the associations of HTR1A C-1019G, HTR2A-1438A/G,...

  • Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia. Juraeva, Dilafruz; Haenisch, Britta; Zapatka, Marc; Frank, Josef; Witt, Stephanie H.; Mühleisen, Thomas W.; Treutlein, Jens; Strohmaier, Jana; Meier, Sandra; Degenhardt, Franziska; Giegling, Ina; Ripke, Stephan; Leber, Markus; Lange, Christoph; Schulze, Thomas G.; Mössner, Rainald; Nenadic, Igor; Sauer, Heinrich; Rujescu, Dan; Maier, Wolfgang // PLoS Genetics;Jun2014, Vol. 10 Issue 6, p1 

    In the present study, an integrated hierarchical approach was applied to: (1) identify pathways associated with susceptibility to schizophrenia; (2) detect genes that may be potentially affected in these pathways since they contain an associated polymorphism; and (3) annotate the functional...

  • Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mah, S; Nelson, M R; DeLisi, L E; Reneland, R H; Markward, N; James, M R; Nyholt, D R; Hayward, N; Handoko, H; Mowry, B; Kammerer, S; Braun, A // Molecular Psychiatry;May2006, Vol. 11 Issue 5, p471 

    The discovery of genetic factors that contribute to schizophrenia susceptibility is a key challenge in understanding the etiology of this disease. Here, we report the identification of a novel schizophrenia candidate gene on chromosome 1q32, plexin A2 (PLXNA2), in a genome-wide association study...

  • A Novel microRNA and transcription factor mediated regulatory network in schizophrenia. An-Yuan Guo; Jingchun Sun; Peilin Jia; Zhongming Zhao // BMC Systems Biology;2010, Vol. 4, p10 

    Background: Schizophrenia is a complex brain disorder with molecular mechanisms that have yet to be elucidated. Previous studies have suggested that changes in gene expression may play an important role in the etiology of schizophrenia, and that microRNAs (miRNAs) and transcription factors (TFs)...

  • Protective Effects of Some Creatine Derivatives in Brain Tissue Anoxia. Luisa Perasso; Gian Lunardi; Federica Risso; Anna Pohvozcheva; Maria Leko; Carlo Gandolfo; Tullio Florio; Aroldo Cupello; Sergey Burov; Maurizio Balestrino // Neurochemical Research;May2008, Vol. 33 Issue 5, p765 

    Abstract  Some derivatives more lipophylic than creatine, thus theoretically being capable to better cross the blood–brain barrier, were studied for their protective effect in mouse hippocampal slices. We found that N-amidino-piperidine is harmful to brain tissue,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics