Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia

Morken, Gunnar; Widen, Jan H.; Grawe, Rolf W.
January 2008
BMC Psychiatry;2008, Vol. 8, Special section p1
Academic Journal
Background: The aims of this study were to describe outcome with respect to persistent psychotic symptoms, relapse of positive symptoms, hospital admissions, and application of treatment by coercion among patients with recent onset schizophrenia being adherent and nonadherent to anti-psychotic medication. Materials and methods: The study included 50 patients with recent onset schizophrenia, schizoaffective or schizophreniform disorders. The patients were clinically stable at study entry and had less than 2 years duration of psychotic symptoms. Good adherence to antipsychotic medication was defined as less than one month without medication. Outcomes for poor and good adherence were compared over a 24-month follow-up period. Results: The Odds Ratio (OR) of having a psychotic relapse was 10.27 and the OR of being admitted to hospital was 4.00 among non-adherent patients. Use of depot-antipsychotics were associated with relapses (OR = 6.44). Conclusion: Non-adherence was associated with relapse, hospital admission and having persistent psychotic symptoms. Interventions to increase adherence are needed. Trial registration: Current Controlled Trials NCT00184509.


Related Articles

  • Psychosis in bipolar and unipolar affective illness with special reference to schizo-affective disorder. Winokur, George; Winokur, G // British Journal of Psychiatry;Sep84, Vol. 145, p236 

    Bipolar and unipolar patients respectively were separated into psychotic and non-psychotic sub-types. The bipolar psychotic patients were more likely to have certain severe symptoms, such as hallucinations and motor abnormalities, than were the unipolar patients, but the family histories of the...

  • A family study of two subgroups of schizoaffective patients. Maj, Mario; Maj, M // British Journal of Psychiatry;May89, Vol. 154, p640 

    A family study was carried out in two groups of patients fulfilling RDC for schizoaffective disorder: in one, a full affective and a full schizophrenic syndrome were simultaneously present; in the other, affective and schizophrenic features appeared within a polymorphic and rapidly changing...

  • The prevalence and diagnostic significance of Schneiderian first-rank symptoms in a random sample of acute psychiatric in-patients. O'Grady, John C.; O'Grady, J C // British Journal of Psychiatry;Apr90, Vol. 156, p496 

    Ninety-nine acute in-patients were interviewed within four days of admission to hospital. The interview included items concerning all 11 first-rank symptoms. Two definitions (wide and narrow) of each first-rank symptom were employed. Three definitions of schizophrenia and a research diagnosis of...

  • Frequency and patterns of coercive measures in acute psychiatric wards in Switzerland. Abderhalden, Christoph; Needham, Ian // BMC Psychiatry;2007 Supplement 1, Vol. 7, Special section p1 

    Background To describe the frequency and nature of coercive measures in admission wards in the German speaking part of Switzerland. Methods We collected during 3 months data on coercive measures in a prospective study on 24 admission wards in 12 psychiatric hospitals in the German speaking part...

  • Seasonal variation in bipolar disorder. Partonen, Timo; Lönnovist, Jouko; Partonen, T; Lönnqvist, J // British Journal of Psychiatry;Nov96, Vol. 169, p641 

    Background: In patients with bipolar disorder, admissions for manic and depressive episodes frequently display a seasonal pattern. We examined this variation and compared the patterns with the seasonal admission rates for schizophrenia.Method: Patients with bipolar...

  • Needs-oriented discharge planning and monitoring for high utilisers of psychiatric services (NODPAM): Design and methods. Puschner, Bernd; Steffen, Sabine; Gaebel, Wolfgang; Freyberger, Harald; Klein, Helmfried E.; Steinert, Tilman; Muche, Rainer; Becker, Thomas // BMC Health Services Research;2008, Vol. 8, Special section p1 

    Background: Attempts to reduce high utilisation of psychiatric inpatient care by targeting the critical time of hospital discharge have been rare. Methods: This paper presents design and methods of the study "Effectiveness and Cost-Effectiveness of Needs-Oriented Discharge Planning and...

  • Adult quality of life and associated factors in adolescent onset schizophrenia and affective psychotic disorders. Jarbin, Håkan; Hansson, Lars; Jarbin, Håkan // Social Psychiatry & Psychiatric Epidemiology;Sep2004, Vol. 39 Issue 9, p725 

    Background: Subjects in treatment for affective disorders are usually less satisfied with life compared to subjects with schizophrenia.Aims: The aims of this study were to compare subjective quality of life (QoL) at adult age of adolescent onset psychotic disorders and...

  • Ziprasidone: zealous in the treatment of schizophrenia and schizoaffective disorder.  // Drugs & Therapy Perspectives;Apr2003, Vol. 19 Issue 4, p1 

    Ziprasidone is a novel atypical antipsychotic with a different pharmacological profile from that of other currently available typical and atypical antipsychotics. It is markedly effective, and apparently at least as effective as haloperidol and olanzapine, in patients with acute exacerbations of...

  • Acute and transient psychotic disorders (ICD-10 F23): a review from a European perspective. Castagnini, Augusto; Berrios, German E. // European Archives of Psychiatry & Clinical Neuroscience;Dec2009, Vol. 259 Issue 8, p433 

    The tenth revision of the International Classification of Mental and Behavioural Disorders (ICD-10) introduced the category F23 ‘Acute and transient psychotic disorders’ (ATPD) to incorporate clinical concepts such as the French bouffée délirante, cycloid psychosis (Germany),...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics