Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia

Morken, Gunnar; Widen, Jan H.; Grawe, Rolf W.
January 2008
BMC Psychiatry;2008, Vol. 8, Special section p1
Academic Journal
Background: The aims of this study were to describe outcome with respect to persistent psychotic symptoms, relapse of positive symptoms, hospital admissions, and application of treatment by coercion among patients with recent onset schizophrenia being adherent and nonadherent to anti-psychotic medication. Materials and methods: The study included 50 patients with recent onset schizophrenia, schizoaffective or schizophreniform disorders. The patients were clinically stable at study entry and had less than 2 years duration of psychotic symptoms. Good adherence to antipsychotic medication was defined as less than one month without medication. Outcomes for poor and good adherence were compared over a 24-month follow-up period. Results: The Odds Ratio (OR) of having a psychotic relapse was 10.27 and the OR of being admitted to hospital was 4.00 among non-adherent patients. Use of depot-antipsychotics were associated with relapses (OR = 6.44). Conclusion: Non-adherence was associated with relapse, hospital admission and having persistent psychotic symptoms. Interventions to increase adherence are needed. Trial registration: Current Controlled Trials NCT00184509.


Related Articles

  • Psychosis in bipolar and unipolar affective illness with special reference to schizo-affective disorder. Winokur, George; Winokur, G // British Journal of Psychiatry;Sep84, Vol. 145, p236 

    Bipolar and unipolar patients respectively were separated into psychotic and non-psychotic sub-types. The bipolar psychotic patients were more likely to have certain severe symptoms, such as hallucinations and motor abnormalities, than were the unipolar patients, but the family histories of the...

  • THE DYNAMICS OF ANTIPSYCHOTIC DRUG USAGE AND HOSPITALISATION IN FOLLOW UP OF SCHIZOPHRENIA PATIENTS. Haukka, J.; Wahlbeck, K.; Klaukka, T.; Lönqvist, J.; Tiihonen, J. // Journal of Epidemiology & Community Health;Aug2004 Supplement 1, Vol. 58, pA27 

    The dynamics of drug usage are of paramount interest when the different medications are compared with naturalistic study approach. The aim of this study was to model the dynamics of antipsychotic drug usage outside the hospital, and hospitalisations. 3232 individuals were followed up after the...

  • Olanzapine versus haloperidol in the treatment of schizoaffective disorder. Iran, Pierre V.; Tollefson, Gary D.; Sanger, Todd M.; Yili Lu; Berg, Paul H.; Beasley Jr., Charles M. // British Journal of Psychiatry;Jan99, Vol. 174, p15 

    Background The effectiveness of antipsychotic monotherapy in schIzoaffective disorder is limited, and further constrained by safety concerns. Aims We aimed to compare the efficacy, tolerability and safety profile of the new pharmaceutical, olanzapine, with haloperidol. Method Data were assessed...

  • Lamotrigine in the Treatment of Schizoaffective Disorder. Erfurth, Andreas; Walden, Jörg; Grunze, Heinz // Neuropsychobiology;1998, Vol. 38 Issue 3, p204 

    There is accumulating evidence for the efficacy of lamotrigine in the treatment of bipolar disorder, including bipolar depression, both as monotherapy and in combination with sodium valproate. We present the cases of 3 female patients admitted to our hospital with the diagnosis of...

  • Frequency and patterns of coercive measures in acute psychiatric wards in Switzerland. Abderhalden, Christoph; Needham, Ian // BMC Psychiatry;2007 Supplement 1, Vol. 7, Special section p1 

    Background To describe the frequency and nature of coercive measures in admission wards in the German speaking part of Switzerland. Methods We collected during 3 months data on coercive measures in a prospective study on 24 admission wards in 12 psychiatric hospitals in the German speaking part...

  • Needs-oriented discharge planning and monitoring for high utilisers of psychiatric services (NODPAM): Design and methods. Puschner, Bernd; Steffen, Sabine; Gaebel, Wolfgang; Freyberger, Harald; Klein, Helmfried E.; Steinert, Tilman; Muche, Rainer; Becker, Thomas // BMC Health Services Research;2008, Vol. 8, Special section p1 

    Background: Attempts to reduce high utilisation of psychiatric inpatient care by targeting the critical time of hospital discharge have been rare. Methods: This paper presents design and methods of the study "Effectiveness and Cost-Effectiveness of Needs-Oriented Discharge Planning and...

  • Seasonal variation in bipolar disorder. Partonen, Timo; Lönnovist, Jouko; Partonen, T; Lönnqvist, J // British Journal of Psychiatry;Nov96, Vol. 169, p641 

    Background: In patients with bipolar disorder, admissions for manic and depressive episodes frequently display a seasonal pattern. We examined this variation and compared the patterns with the seasonal admission rates for schizophrenia.Method: Patients with bipolar...

  • Inner london collaborative audit of admission in two health districts. III: Reasons for acute admission to psychiatric wards. Flannigan, C. B.; Glover, G. A.; Wing, J. K.; Lewis, S. W.; Bebbington, P. E.; Feeney, S. T.; Glover, G R // British Journal of Psychiatry;Dec94, Vol. 165, p750 

    Background: In this series, rates of admission and daily bed use in south Southwark were 30% higher than in Hammersmith & Fulham, principally because of a higher rate of admission for affective disorders. Factors associated with compulsory admission did not differ between the...

  • Lithium Combined with Haloperidol in Schizophrenic Patients. Leaner, Yaacov; Mintzer, Yaacov; Schestatziky, Miguel // British Journal of Psychiatry;Sep88, Vol. 153, p359 

    Previously, the addition of lithium to haloperidol has been reported to be of modest benefit to schizoaffective patients. To test this treatment on a different sample, 36 mainly schizophrenic patients were subdivided on the basis of the median of their initial depression score on the BPRS into...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics