COMPARE: Two preparations of carvedilol comparable in patients with HF

November 2008
Cardiology Today;Nov2008, Vol. 11 Issue 11, p19
The article reports that researchers for the Study to Compare the Effects of Coreg Controlled-Release (CR) and Coreg Instant-Release (IR) on Heart Failure (HF) in Subjects with Stable Chronic HF (COMPARE) indicate that two preparations of carvedilol given to patients with HF were found almost bioequivalent. In their study of 253 patients with stable chronic HF, Dr. Barry H. Greenberg of the University of California states that the Coreg CR showed noninferiority to the Coreg IR and this demonstrates comparable efficacy between the two.


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